Curcumin targets the TFEB-lysosome pathway for induction of autophagy

• Main Authors: Zhang, J, Wang, J, Xu, J, Lu, Y, Jiang, J, Wang, L, Shen, H.-M, Xia, D
• Other Authors: SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
• Format: Article
• Published: Impact Journals LLC 2020
• Subjects: curcumin; mammalian target of rapamycin; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase 1; protein kinase B; protein S6; transcription factor; transcription factor EB; unclassified drug; antineoplastic agent; basic helix loop helix leucine zipper transcription factor; MTOR protein, human; protein binding; target of rapamycin kinase; TFEB protein, human; acidification; animal cell; antineoplastic activity; Article; autophagy; cell death; cell survival; concentration response; controlled study; drug mechanism; drug protein binding; embryo; enzyme activity; enzyme phosphorylation; enzyme repression; fibroblast; HCT116 cell line; human; human cell; lysosome; mouse; nonhuman; protein cleavage; protein expression; protein phosphorylation; animal; antagonists and inhibitors; cell line; drug effects; gene knockout; genetics; HCT 116 cell line; metabolism; signal transduction; transcription initiation; Animals; Antineoplastic Agents, Phytogenic; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Line; Cell Survival; Curcumin; Fibroblasts; Gene Knockout Techniques; HCT116 Cells; Humans; Lysosomes; Mice; Protein Binding; Signal Transduction; TOR Serine-Threonine Kinases; Transcriptional Activation
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175451
• Institution: National University of Singapore

10.18632/oncotarget.12318