PRIMA-1 targets the vulnerability of multiple myeloma of deregulated protein homeostasis through the perturbation of ER stress via p73 demethylation

10.18632/oncotarget.11241

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Main Authors:	Teoh P.J., Bi C., Sintosebastian C., Tay L.S., Fonseca R., Chng W.J.
Other Authors:	CANCER SCIENCE INSTITUTE OF SINGAPORE
Format:	Article
Published:	Impact Journals LLC 2020
Subjects:	antineoplastic agent bortezomib growth arrest and DNA damage inducible protein 153 heat shock protein 70 initiation factor 2alpha membrane protein messenger RNA nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase p53 reactivation and induction of massive apoptosis 1 protein GADD34 protein p53 protein p73 unclassified drug activating transcription factor 6 ATF6 protein, human DNA (cytosine 5) methyltransferase 1 DNMT1 protein, human ERN1 protein, human nerve protein p73 protein, human PRIMA1 protein, human protein serine threonine kinase ribonuclease tumor protein p73 antineoplastic activity apoptosis Article bioinformatics cancer inhibition cell survival cell viability concentration response controlled study demethylation drug cytotoxicity drug mechanism drug potency drug sensitization drug targeting endoplasmic reticulum stress gene genotype human human cell IC50 intracellular signaling molecular dynamics multiple myeloma myeloma cell protein conformation protein expression protein homeostasis protein phosphorylation TP73 gene transcription regulation unfolded protein response upregulation DNA methylation endoplasmic reticulum gene expression regulation gene silencing genetic transcription genome-wide association study homeostasis metabolism tumor cell line Activating Transcription Factor 6 Apoptosis Bortezomib Cell Line, Tumor Cell Survival DNA (Cytosine-5-)-Methyltransferase 1 DNA Methylation Endoplasmic Reticulum Endoribonucleases Gene Expression Regulation, Neoplastic Gene Silencing Genome-Wide Association Study Genotype Homeostasis Humans Membrane Proteins Multiple Myeloma Nerve Tissue Proteins Protein-Serine-Threonine Kinases Transcription, Genetic Tumor Protein p73 Unfolded Protein Response Up-Regulation
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/175452
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spelling	sg-nus-scholar.10635-1754522024-05-08T09:51:50Z PRIMA-1 targets the vulnerability of multiple myeloma of deregulated protein homeostasis through the perturbation of ER stress via p73 demethylation Teoh P.J. Bi C. Sintosebastian C. Tay L.S. Fonseca R. Chng W.J. CANCER SCIENCE INSTITUTE OF SINGAPORE MEDICINE antineoplastic agent bortezomib growth arrest and DNA damage inducible protein 153 heat shock protein 70 initiation factor 2alpha membrane protein messenger RNA nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase p53 reactivation and induction of massive apoptosis 1 protein GADD34 protein p53 protein p73 unclassified drug activating transcription factor 6 ATF6 protein, human bortezomib DNA (cytosine 5) methyltransferase 1 DNMT1 protein, human ERN1 protein, human membrane protein nerve protein p73 protein, human PRIMA1 protein, human protein serine threonine kinase ribonuclease tumor protein p73 antineoplastic activity apoptosis Article bioinformatics cancer inhibition cell survival cell viability concentration response controlled study demethylation drug cytotoxicity drug mechanism drug potency drug sensitization drug targeting endoplasmic reticulum stress gene genotype human human cell IC50 intracellular signaling molecular dynamics multiple myeloma myeloma cell protein conformation protein expression protein homeostasis protein phosphorylation TP73 gene transcription regulation unfolded protein response upregulation DNA methylation endoplasmic reticulum gene expression regulation gene silencing genetic transcription genome-wide association study homeostasis metabolism multiple myeloma tumor cell line Activating Transcription Factor 6 Apoptosis Bortezomib Cell Line, Tumor Cell Survival DNA (Cytosine-5-)-Methyltransferase 1 DNA Methylation Endoplasmic Reticulum Endoribonucleases Gene Expression Regulation, Neoplastic Gene Silencing Genome-Wide Association Study Genotype Homeostasis Humans Membrane Proteins Multiple Myeloma Nerve Tissue Proteins Protein-Serine-Threonine Kinases Transcription, Genetic Tumor Protein p73 Unfolded Protein Response Up-Regulation 10.18632/oncotarget.11241 Oncotarget 7 38 61806-61819 2020-09-10T01:44:12Z 2020-09-10T01:44:12Z 2016 Article Teoh P.J., Bi C., Sintosebastian C., Tay L.S., Fonseca R., Chng W.J. (2016). PRIMA-1 targets the vulnerability of multiple myeloma of deregulated protein homeostasis through the perturbation of ER stress via p73 demethylation. Oncotarget 7 (38) : 61806-61819. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.11241 19492553 https://scholarbank.nus.edu.sg/handle/10635/175452 Impact Journals LLC Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	antineoplastic agent bortezomib growth arrest and DNA damage inducible protein 153 heat shock protein 70 initiation factor 2alpha membrane protein messenger RNA nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase p53 reactivation and induction of massive apoptosis 1 protein GADD34 protein p53 protein p73 unclassified drug activating transcription factor 6 ATF6 protein, human bortezomib DNA (cytosine 5) methyltransferase 1 DNMT1 protein, human ERN1 protein, human membrane protein nerve protein p73 protein, human PRIMA1 protein, human protein serine threonine kinase ribonuclease tumor protein p73 antineoplastic activity apoptosis Article bioinformatics cancer inhibition cell survival cell viability concentration response controlled study demethylation drug cytotoxicity drug mechanism drug potency drug sensitization drug targeting endoplasmic reticulum stress gene genotype human human cell IC50 intracellular signaling molecular dynamics multiple myeloma myeloma cell protein conformation protein expression protein homeostasis protein phosphorylation TP73 gene transcription regulation unfolded protein response upregulation DNA methylation endoplasmic reticulum gene expression regulation gene silencing genetic transcription genome-wide association study homeostasis metabolism multiple myeloma tumor cell line Activating Transcription Factor 6 Apoptosis Bortezomib Cell Line, Tumor Cell Survival DNA (Cytosine-5-)-Methyltransferase 1 DNA Methylation Endoplasmic Reticulum Endoribonucleases Gene Expression Regulation, Neoplastic Gene Silencing Genome-Wide Association Study Genotype Homeostasis Humans Membrane Proteins Multiple Myeloma Nerve Tissue Proteins Protein-Serine-Threonine Kinases Transcription, Genetic Tumor Protein p73 Unfolded Protein Response Up-Regulation
spellingShingle	antineoplastic agent bortezomib growth arrest and DNA damage inducible protein 153 heat shock protein 70 initiation factor 2alpha membrane protein messenger RNA nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase p53 reactivation and induction of massive apoptosis 1 protein GADD34 protein p53 protein p73 unclassified drug activating transcription factor 6 ATF6 protein, human bortezomib DNA (cytosine 5) methyltransferase 1 DNMT1 protein, human ERN1 protein, human membrane protein nerve protein p73 protein, human PRIMA1 protein, human protein serine threonine kinase ribonuclease tumor protein p73 antineoplastic activity apoptosis Article bioinformatics cancer inhibition cell survival cell viability concentration response controlled study demethylation drug cytotoxicity drug mechanism drug potency drug sensitization drug targeting endoplasmic reticulum stress gene genotype human human cell IC50 intracellular signaling molecular dynamics multiple myeloma myeloma cell protein conformation protein expression protein homeostasis protein phosphorylation TP73 gene transcription regulation unfolded protein response upregulation DNA methylation endoplasmic reticulum gene expression regulation gene silencing genetic transcription genome-wide association study homeostasis metabolism multiple myeloma tumor cell line Activating Transcription Factor 6 Apoptosis Bortezomib Cell Line, Tumor Cell Survival DNA (Cytosine-5-)-Methyltransferase 1 DNA Methylation Endoplasmic Reticulum Endoribonucleases Gene Expression Regulation, Neoplastic Gene Silencing Genome-Wide Association Study Genotype Homeostasis Humans Membrane Proteins Multiple Myeloma Nerve Tissue Proteins Protein-Serine-Threonine Kinases Transcription, Genetic Tumor Protein p73 Unfolded Protein Response Up-Regulation Teoh P.J. Bi C. Sintosebastian C. Tay L.S. Fonseca R. Chng W.J. PRIMA-1 targets the vulnerability of multiple myeloma of deregulated protein homeostasis through the perturbation of ER stress via p73 demethylation
description	10.18632/oncotarget.11241
author2	CANCER SCIENCE INSTITUTE OF SINGAPORE
author_facet	CANCER SCIENCE INSTITUTE OF SINGAPORE Teoh P.J. Bi C. Sintosebastian C. Tay L.S. Fonseca R. Chng W.J.
format	Article
author	Teoh P.J. Bi C. Sintosebastian C. Tay L.S. Fonseca R. Chng W.J.
author_sort	Teoh P.J.
title	PRIMA-1 targets the vulnerability of multiple myeloma of deregulated protein homeostasis through the perturbation of ER stress via p73 demethylation
title_short	PRIMA-1 targets the vulnerability of multiple myeloma of deregulated protein homeostasis through the perturbation of ER stress via p73 demethylation
title_full	PRIMA-1 targets the vulnerability of multiple myeloma of deregulated protein homeostasis through the perturbation of ER stress via p73 demethylation
title_fullStr	PRIMA-1 targets the vulnerability of multiple myeloma of deregulated protein homeostasis through the perturbation of ER stress via p73 demethylation
title_full_unstemmed	PRIMA-1 targets the vulnerability of multiple myeloma of deregulated protein homeostasis through the perturbation of ER stress via p73 demethylation
title_sort	prima-1 targets the vulnerability of multiple myeloma of deregulated protein homeostasis through the perturbation of er stress via p73 demethylation
publisher	Impact Journals LLC
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/175452
_version_	1800914370357624832

PRIMA-1 targets the vulnerability of multiple myeloma of deregulated protein homeostasis through the perturbation of ER stress via p73 demethylation

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