PRIMA-1 targets the vulnerability of multiple myeloma of deregulated protein homeostasis through the perturbation of ER stress via p73 demethylation

• Main Authors: Teoh P.J., Bi C., Sintosebastian C., Tay L.S., Fonseca R., Chng W.J.
• Other Authors: CANCER SCIENCE INSTITUTE OF SINGAPORE
• Format: Article
• Published: Impact Journals LLC 2020
• Subjects: antineoplastic agent; bortezomib; growth arrest and DNA damage inducible protein 153; heat shock protein 70; initiation factor 2alpha; membrane protein; messenger RNA; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; p53 reactivation and induction of massive apoptosis 1; protein GADD34; protein p53; protein p73; unclassified drug; activating transcription factor 6; ATF6 protein, human; DNA (cytosine 5) methyltransferase 1; DNMT1 protein, human; ERN1 protein, human; nerve protein; p73 protein, human; PRIMA1 protein, human; protein serine threonine kinase; ribonuclease; tumor protein p73; antineoplastic activity; apoptosis; Article; bioinformatics; cancer inhibition; cell survival; cell viability; concentration response; controlled study; demethylation; drug cytotoxicity; drug mechanism; drug potency; drug sensitization; drug targeting; endoplasmic reticulum stress; gene; genotype; human; human cell; IC50; intracellular signaling; molecular dynamics; multiple myeloma; myeloma cell; protein conformation; protein expression; protein homeostasis; protein phosphorylation; TP73 gene; transcription regulation; unfolded protein response; upregulation; DNA methylation; endoplasmic reticulum; gene expression regulation; gene silencing; genetic transcription; genome-wide association study; homeostasis; metabolism; tumor cell line; Activating Transcription Factor 6; Apoptosis; Bortezomib; Cell Line, Tumor; Cell Survival; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; Endoplasmic Reticulum; Endoribonucleases; Gene Expression Regulation, Neoplastic; Gene Silencing; Genome-Wide Association Study; Genotype; Homeostasis; Humans; Membrane Proteins; Multiple Myeloma; Nerve Tissue Proteins; Protein-Serine-Threonine Kinases; Transcription, Genetic; Tumor Protein p73; Unfolded Protein Response; Up-Regulation
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175452
• Institution: National University of Singapore

10.18632/oncotarget.11241