Inhibition of p300 Lysine Acetyltransferase activity by Luteolin reduces tumor growth in head and neck squamous cell carcinoma (HNSCC) xenograft mouse model

10.18632/oncotarget.6245

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Main Authors:	Selvi, R.B, Swaminathan, A, Chatterjee, S, Shanmugam, M.K, Li, F, Ramakrishnan, G.B, Siveen, K.S, Chinnathambi, A, Emam Zayed, M, Alharbi, S.A, Basha, J, Bhat, A, Vasudevan, M, Dharmarajan, A, Sethi, G, Kundu, T.K
Other Authors:	DEPT OF PHARMACOLOGY
Format:	Article
Published:	Impact Journals LLC 2020
Subjects:	acetyl coenzyme A E1A associated p300 protein histone luteolin microRNA microRNA 135a microRNA 195 microRNA 215 microRNA let7C protein p53 unclassified drug antineoplastic agent histone acetyltransferase PCAF lysine p300-CBP-associated factor transcriptome animal experiment animal model animal tissue antineoplastic activity Article binding competition cancer inhibition cell cycle arrest chromatin immunoprecipitation controlled study down regulation drug binding site drug efficacy enzyme activity enzyme inhibition gene expression profiling gene expression regulation gene ontology head and neck squamous cell carcinoma histone acetylation human human cell migration inhibition mouse mouse model nonhuman promoter region RNA processing treatment duration tumor xenograft animal cell proliferation DNA microarray drug effects drug screening flow cytometry head and neck tumor immunoblotting immunohistochemistry metabolism molecular docking pathology squamous cell carcinoma Animals Antineoplastic Agents Carcinoma, Squamous Cell Cell Proliferation Chromatin Immunoprecipitation Flow Cytometry Head and Neck Neoplasms Humans Immunoblotting Immunohistochemistry Luteolin Lysine Mice Molecular Docking Simulation Oligonucleotide Array Sequence Analysis p300-CBP Transcription Factors Transcriptome Xenograft Model Antitumor Assays
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/175520
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1755202020-09-10T13:35:15Z Inhibition of p300 Lysine Acetyltransferase activity by Luteolin reduces tumor growth in head and neck squamous cell carcinoma (HNSCC) xenograft mouse model Selvi, R.B Swaminathan, A Chatterjee, S Shanmugam, M.K Li, F Ramakrishnan, G.B Siveen, K.S Chinnathambi, A Emam Zayed, M Alharbi, S.A Basha, J Bhat, A Vasudevan, M Dharmarajan, A Sethi, G Kundu, T.K DEPT OF PHARMACOLOGY CANCER SCIENCE INSTITUTE OF SINGAPORE acetyl coenzyme A E1A associated p300 protein histone luteolin microRNA microRNA 135a microRNA 195 microRNA 215 microRNA let7C protein p53 unclassified drug antineoplastic agent histone acetyltransferase PCAF luteolin lysine p300-CBP-associated factor transcriptome animal experiment animal model animal tissue antineoplastic activity Article binding competition cancer inhibition cell cycle arrest chromatin immunoprecipitation controlled study down regulation drug binding site drug efficacy enzyme activity enzyme inhibition gene expression profiling gene expression regulation gene ontology head and neck squamous cell carcinoma histone acetylation human human cell migration inhibition mouse mouse model nonhuman promoter region RNA processing treatment duration tumor xenograft animal cell proliferation DNA microarray drug effects drug screening flow cytometry head and neck tumor immunoblotting immunohistochemistry metabolism molecular docking pathology squamous cell carcinoma Animals Antineoplastic Agents Carcinoma, Squamous Cell Cell Proliferation Chromatin Immunoprecipitation Flow Cytometry Head and Neck Neoplasms Humans Immunoblotting Immunohistochemistry Luteolin Lysine Mice Molecular Docking Simulation Oligonucleotide Array Sequence Analysis p300-CBP Transcription Factors Transcriptome Xenograft Model Antitumor Assays 10.18632/oncotarget.6245 Oncotarget 6 41 43806-43818 2020-09-10T01:59:29Z 2020-09-10T01:59:29Z 2015 Article Selvi, R.B, Swaminathan, A, Chatterjee, S, Shanmugam, M.K, Li, F, Ramakrishnan, G.B, Siveen, K.S, Chinnathambi, A, Emam Zayed, M, Alharbi, S.A, Basha, J, Bhat, A, Vasudevan, M, Dharmarajan, A, Sethi, G, Kundu, T.K (2015). Inhibition of p300 Lysine Acetyltransferase activity by Luteolin reduces tumor growth in head and neck squamous cell carcinoma (HNSCC) xenograft mouse model. Oncotarget 6 (41) : 43806-43818. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.6245 19492553 https://scholarbank.nus.edu.sg/handle/10635/175520 Impact Journals LLC Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
country	Singapore
collection	ScholarBank@NUS
topic	acetyl coenzyme A E1A associated p300 protein histone luteolin microRNA microRNA 135a microRNA 195 microRNA 215 microRNA let7C protein p53 unclassified drug antineoplastic agent histone acetyltransferase PCAF luteolin lysine p300-CBP-associated factor transcriptome animal experiment animal model animal tissue antineoplastic activity Article binding competition cancer inhibition cell cycle arrest chromatin immunoprecipitation controlled study down regulation drug binding site drug efficacy enzyme activity enzyme inhibition gene expression profiling gene expression regulation gene ontology head and neck squamous cell carcinoma histone acetylation human human cell migration inhibition mouse mouse model nonhuman promoter region RNA processing treatment duration tumor xenograft animal cell proliferation DNA microarray drug effects drug screening flow cytometry head and neck tumor immunoblotting immunohistochemistry metabolism molecular docking pathology squamous cell carcinoma Animals Antineoplastic Agents Carcinoma, Squamous Cell Cell Proliferation Chromatin Immunoprecipitation Flow Cytometry Head and Neck Neoplasms Humans Immunoblotting Immunohistochemistry Luteolin Lysine Mice Molecular Docking Simulation Oligonucleotide Array Sequence Analysis p300-CBP Transcription Factors Transcriptome Xenograft Model Antitumor Assays
spellingShingle	acetyl coenzyme A E1A associated p300 protein histone luteolin microRNA microRNA 135a microRNA 195 microRNA 215 microRNA let7C protein p53 unclassified drug antineoplastic agent histone acetyltransferase PCAF luteolin lysine p300-CBP-associated factor transcriptome animal experiment animal model animal tissue antineoplastic activity Article binding competition cancer inhibition cell cycle arrest chromatin immunoprecipitation controlled study down regulation drug binding site drug efficacy enzyme activity enzyme inhibition gene expression profiling gene expression regulation gene ontology head and neck squamous cell carcinoma histone acetylation human human cell migration inhibition mouse mouse model nonhuman promoter region RNA processing treatment duration tumor xenograft animal cell proliferation DNA microarray drug effects drug screening flow cytometry head and neck tumor immunoblotting immunohistochemistry metabolism molecular docking pathology squamous cell carcinoma Animals Antineoplastic Agents Carcinoma, Squamous Cell Cell Proliferation Chromatin Immunoprecipitation Flow Cytometry Head and Neck Neoplasms Humans Immunoblotting Immunohistochemistry Luteolin Lysine Mice Molecular Docking Simulation Oligonucleotide Array Sequence Analysis p300-CBP Transcription Factors Transcriptome Xenograft Model Antitumor Assays Selvi, R.B Swaminathan, A Chatterjee, S Shanmugam, M.K Li, F Ramakrishnan, G.B Siveen, K.S Chinnathambi, A Emam Zayed, M Alharbi, S.A Basha, J Bhat, A Vasudevan, M Dharmarajan, A Sethi, G Kundu, T.K Inhibition of p300 Lysine Acetyltransferase activity by Luteolin reduces tumor growth in head and neck squamous cell carcinoma (HNSCC) xenograft mouse model
description	10.18632/oncotarget.6245
author2	DEPT OF PHARMACOLOGY
author_facet	DEPT OF PHARMACOLOGY Selvi, R.B Swaminathan, A Chatterjee, S Shanmugam, M.K Li, F Ramakrishnan, G.B Siveen, K.S Chinnathambi, A Emam Zayed, M Alharbi, S.A Basha, J Bhat, A Vasudevan, M Dharmarajan, A Sethi, G Kundu, T.K
format	Article
author	Selvi, R.B Swaminathan, A Chatterjee, S Shanmugam, M.K Li, F Ramakrishnan, G.B Siveen, K.S Chinnathambi, A Emam Zayed, M Alharbi, S.A Basha, J Bhat, A Vasudevan, M Dharmarajan, A Sethi, G Kundu, T.K
author_sort	Selvi, R.B
title	Inhibition of p300 Lysine Acetyltransferase activity by Luteolin reduces tumor growth in head and neck squamous cell carcinoma (HNSCC) xenograft mouse model
title_short	Inhibition of p300 Lysine Acetyltransferase activity by Luteolin reduces tumor growth in head and neck squamous cell carcinoma (HNSCC) xenograft mouse model
title_full	Inhibition of p300 Lysine Acetyltransferase activity by Luteolin reduces tumor growth in head and neck squamous cell carcinoma (HNSCC) xenograft mouse model
title_fullStr	Inhibition of p300 Lysine Acetyltransferase activity by Luteolin reduces tumor growth in head and neck squamous cell carcinoma (HNSCC) xenograft mouse model
title_full_unstemmed	Inhibition of p300 Lysine Acetyltransferase activity by Luteolin reduces tumor growth in head and neck squamous cell carcinoma (HNSCC) xenograft mouse model
title_sort	inhibition of p300 lysine acetyltransferase activity by luteolin reduces tumor growth in head and neck squamous cell carcinoma (hnscc) xenograft mouse model
publisher	Impact Journals LLC
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/175520
_version_	1681101947537457152

Inhibition of p300 Lysine Acetyltransferase activity by Luteolin reduces tumor growth in head and neck squamous cell carcinoma (HNSCC) xenograft mouse model

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