Inhibition of p300 Lysine Acetyltransferase activity by Luteolin reduces tumor growth in head and neck squamous cell carcinoma (HNSCC) xenograft mouse model

• Main Authors: Selvi, R.B, Swaminathan, A, Chatterjee, S, Shanmugam, M.K, Li, F, Ramakrishnan, G.B, Siveen, K.S, Chinnathambi, A, Emam Zayed, M, Alharbi, S.A, Basha, J, Bhat, A, Vasudevan, M, Dharmarajan, A, Sethi, G, Kundu, T.K
• Other Authors: DEPT OF PHARMACOLOGY
• Format: Article
• Published: Impact Journals LLC 2020
• Subjects: acetyl coenzyme A; E1A associated p300 protein; histone; luteolin; microRNA; microRNA 135a; microRNA 195; microRNA 215; microRNA let7C; protein p53; unclassified drug; antineoplastic agent; histone acetyltransferase PCAF; lysine; p300-CBP-associated factor; transcriptome; animal experiment; animal model; animal tissue; antineoplastic activity; Article; binding competition; cancer inhibition; cell cycle arrest; chromatin immunoprecipitation; controlled study; down regulation; drug binding site; drug efficacy; enzyme activity; enzyme inhibition; gene expression profiling; gene expression regulation; gene ontology; head and neck squamous cell carcinoma; histone acetylation; human; human cell; migration inhibition; mouse; mouse model; nonhuman; promoter region; RNA processing; treatment duration; tumor xenograft; animal; cell proliferation; DNA microarray; drug effects; drug screening; flow cytometry; head and neck tumor; immunoblotting; immunohistochemistry; metabolism; molecular docking; pathology; squamous cell carcinoma; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Proliferation; Chromatin Immunoprecipitation; Flow Cytometry; Head and Neck Neoplasms; Humans; Immunoblotting; Immunohistochemistry; Luteolin; Lysine; Mice; Molecular Docking Simulation; Oligonucleotide Array Sequence Analysis; p300-CBP Transcription Factors; Transcriptome; Xenograft Model Antitumor Assays
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175520
• Institution: National University of Singapore

10.18632/oncotarget.6245