VHL deficiency drives enhancer activation of oncogenes in clear cell renal cell carcinoma

10.1158/2159-8290.CD-17-0375

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Main Authors: Yao, X, Tan, J, Lim, K.J, Koh, J, Ooi, W.F, Li, Z, Huang, D, Xing, M, Chan, Y.S, Qu, J.Z, Tay, S.T, Wijaya, G, Lam, Y.N, Hong, J.H, Lee-Lim, A.P, Guan, P, Ng, M.S.W, He, C.Z, Lin, J.S, Nandi, T, Qamra, A, Xu, C, Myint, S.S, Davies, J.O.J, Goh, J.Y, Loh, G, Tan, B.C, Rozen, S.G, Yu, Q, Tan, I.B.H, Cheng, C.W.S, Li, S, Chang, K.T.E, Tan, P.H, Silver, D.L, Lezhava, A, Steger, G, Hughes, J.R, Teh, B.T, Tan, P
Other Authors: PHYSIOLOGY
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Published: 2020
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Online Access:https://scholarbank.nus.edu.sg/handle/10635/176072
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spelling sg-nus-scholar.10635-1760722024-11-15T01:21:06Z VHL deficiency drives enhancer activation of oncogenes in clear cell renal cell carcinoma Yao, X Tan, J Lim, K.J Koh, J Ooi, W.F Li, Z Huang, D Xing, M Chan, Y.S Qu, J.Z Tay, S.T Wijaya, G Lam, Y.N Hong, J.H Lee-Lim, A.P Guan, P Ng, M.S.W He, C.Z Lin, J.S Nandi, T Qamra, A Xu, C Myint, S.S Davies, J.O.J Goh, J.Y Loh, G Tan, B.C Rozen, S.G Yu, Q Tan, I.B.H Cheng, C.W.S Li, S Chang, K.T.E Tan, P.H Silver, D.L Lezhava, A Steger, G Hughes, J.R Teh, B.T Tan, P PHYSIOLOGY DUKE-NUS MEDICAL SCHOOL chemokine receptor CXCR4 glucose transporter 1 hypoxia inducible factor 1alpha vasculotropin A von Hippel Lindau protein basic helix loop helix transcription factor DNA binding protein endothelial PAS domain-containing protein 1 histone acetyltransferase PCAF p300-CBP-associated factor transcription factor VHL protein, human von Hippel Lindau protein ZNF395 protein, human Article carcinogenesis controlled study DNA methylation gene activation gene expression gene sequence human human cell immunoblotting immunoprecipitation oncogene polymerase chain reaction principal component analysis promoter region protein deficiency protein interaction renal cell carcinoma chromatin enhancer region gene expression regulation genetics mutation oncogene pathology regulatory sequence renal cell carcinoma tumor cell line Basic Helix-Loop-Helix Transcription Factors Carcinogenesis Carcinoma, Renal Cell Cell Line, Tumor Chromatin DNA-Binding Proteins Enhancer Elements, Genetic Gene Expression Regulation, Neoplastic Humans Mutation Oncogenes p300-CBP Transcription Factors Promoter Regions, Genetic Regulatory Sequences, Nucleic Acid Transcription Factors Von Hippel-Lindau Tumor Suppressor Protein 10.1158/2159-8290.CD-17-0375 Cancer Discovery 7 11 1284-1305 2020-09-14T07:59:07Z 2020-09-14T07:59:07Z 2017 Article Yao, X, Tan, J, Lim, K.J, Koh, J, Ooi, W.F, Li, Z, Huang, D, Xing, M, Chan, Y.S, Qu, J.Z, Tay, S.T, Wijaya, G, Lam, Y.N, Hong, J.H, Lee-Lim, A.P, Guan, P, Ng, M.S.W, He, C.Z, Lin, J.S, Nandi, T, Qamra, A, Xu, C, Myint, S.S, Davies, J.O.J, Goh, J.Y, Loh, G, Tan, B.C, Rozen, S.G, Yu, Q, Tan, I.B.H, Cheng, C.W.S, Li, S, Chang, K.T.E, Tan, P.H, Silver, D.L, Lezhava, A, Steger, G, Hughes, J.R, Teh, B.T, Tan, P (2017). VHL deficiency drives enhancer activation of oncogenes in clear cell renal cell carcinoma. Cancer Discovery 7 (11) : 1284-1305. ScholarBank@NUS Repository. https://doi.org/10.1158/2159-8290.CD-17-0375 2159-8274 https://scholarbank.nus.edu.sg/handle/10635/176072 Unpaywall 20200831
institution National University of Singapore
building NUS Library
continent Asia
country Singapore
Singapore
content_provider NUS Library
collection ScholarBank@NUS
topic chemokine receptor CXCR4
glucose transporter 1
hypoxia inducible factor 1alpha
vasculotropin A
von Hippel Lindau protein
basic helix loop helix transcription factor
DNA binding protein
endothelial PAS domain-containing protein 1
histone acetyltransferase PCAF
p300-CBP-associated factor
transcription factor
VHL protein, human
von Hippel Lindau protein
ZNF395 protein, human
Article
carcinogenesis
controlled study
DNA methylation
gene activation
gene expression
gene sequence
human
human cell
immunoblotting
immunoprecipitation
oncogene
polymerase chain reaction
principal component analysis
promoter region
protein deficiency
protein interaction
renal cell carcinoma
chromatin
enhancer region
gene expression regulation
genetics
mutation
oncogene
pathology
regulatory sequence
renal cell carcinoma
tumor cell line
Basic Helix-Loop-Helix Transcription Factors
Carcinogenesis
Carcinoma, Renal Cell
Cell Line, Tumor
Chromatin
DNA-Binding Proteins
Enhancer Elements, Genetic
Gene Expression Regulation, Neoplastic
Humans
Mutation
Oncogenes
p300-CBP Transcription Factors
Promoter Regions, Genetic
Regulatory Sequences, Nucleic Acid
Transcription Factors
Von Hippel-Lindau Tumor Suppressor Protein
spellingShingle chemokine receptor CXCR4
glucose transporter 1
hypoxia inducible factor 1alpha
vasculotropin A
von Hippel Lindau protein
basic helix loop helix transcription factor
DNA binding protein
endothelial PAS domain-containing protein 1
histone acetyltransferase PCAF
p300-CBP-associated factor
transcription factor
VHL protein, human
von Hippel Lindau protein
ZNF395 protein, human
Article
carcinogenesis
controlled study
DNA methylation
gene activation
gene expression
gene sequence
human
human cell
immunoblotting
immunoprecipitation
oncogene
polymerase chain reaction
principal component analysis
promoter region
protein deficiency
protein interaction
renal cell carcinoma
chromatin
enhancer region
gene expression regulation
genetics
mutation
oncogene
pathology
regulatory sequence
renal cell carcinoma
tumor cell line
Basic Helix-Loop-Helix Transcription Factors
Carcinogenesis
Carcinoma, Renal Cell
Cell Line, Tumor
Chromatin
DNA-Binding Proteins
Enhancer Elements, Genetic
Gene Expression Regulation, Neoplastic
Humans
Mutation
Oncogenes
p300-CBP Transcription Factors
Promoter Regions, Genetic
Regulatory Sequences, Nucleic Acid
Transcription Factors
Von Hippel-Lindau Tumor Suppressor Protein
Yao, X
Tan, J
Lim, K.J
Koh, J
Ooi, W.F
Li, Z
Huang, D
Xing, M
Chan, Y.S
Qu, J.Z
Tay, S.T
Wijaya, G
Lam, Y.N
Hong, J.H
Lee-Lim, A.P
Guan, P
Ng, M.S.W
He, C.Z
Lin, J.S
Nandi, T
Qamra, A
Xu, C
Myint, S.S
Davies, J.O.J
Goh, J.Y
Loh, G
Tan, B.C
Rozen, S.G
Yu, Q
Tan, I.B.H
Cheng, C.W.S
Li, S
Chang, K.T.E
Tan, P.H
Silver, D.L
Lezhava, A
Steger, G
Hughes, J.R
Teh, B.T
Tan, P
VHL deficiency drives enhancer activation of oncogenes in clear cell renal cell carcinoma
description 10.1158/2159-8290.CD-17-0375
author2 PHYSIOLOGY
author_facet PHYSIOLOGY
Yao, X
Tan, J
Lim, K.J
Koh, J
Ooi, W.F
Li, Z
Huang, D
Xing, M
Chan, Y.S
Qu, J.Z
Tay, S.T
Wijaya, G
Lam, Y.N
Hong, J.H
Lee-Lim, A.P
Guan, P
Ng, M.S.W
He, C.Z
Lin, J.S
Nandi, T
Qamra, A
Xu, C
Myint, S.S
Davies, J.O.J
Goh, J.Y
Loh, G
Tan, B.C
Rozen, S.G
Yu, Q
Tan, I.B.H
Cheng, C.W.S
Li, S
Chang, K.T.E
Tan, P.H
Silver, D.L
Lezhava, A
Steger, G
Hughes, J.R
Teh, B.T
Tan, P
format Article
author Yao, X
Tan, J
Lim, K.J
Koh, J
Ooi, W.F
Li, Z
Huang, D
Xing, M
Chan, Y.S
Qu, J.Z
Tay, S.T
Wijaya, G
Lam, Y.N
Hong, J.H
Lee-Lim, A.P
Guan, P
Ng, M.S.W
He, C.Z
Lin, J.S
Nandi, T
Qamra, A
Xu, C
Myint, S.S
Davies, J.O.J
Goh, J.Y
Loh, G
Tan, B.C
Rozen, S.G
Yu, Q
Tan, I.B.H
Cheng, C.W.S
Li, S
Chang, K.T.E
Tan, P.H
Silver, D.L
Lezhava, A
Steger, G
Hughes, J.R
Teh, B.T
Tan, P
author_sort Yao, X
title VHL deficiency drives enhancer activation of oncogenes in clear cell renal cell carcinoma
title_short VHL deficiency drives enhancer activation of oncogenes in clear cell renal cell carcinoma
title_full VHL deficiency drives enhancer activation of oncogenes in clear cell renal cell carcinoma
title_fullStr VHL deficiency drives enhancer activation of oncogenes in clear cell renal cell carcinoma
title_full_unstemmed VHL deficiency drives enhancer activation of oncogenes in clear cell renal cell carcinoma
title_sort vhl deficiency drives enhancer activation of oncogenes in clear cell renal cell carcinoma
publishDate 2020
url https://scholarbank.nus.edu.sg/handle/10635/176072
_version_ 1821195596816449536