Architecture of polymorphisms in the human genome reveals functionally important and positively selected variants in immune response and drug transporter genes

10.1186/s40246-018-0175-1

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Main Authors:	Jin, Y, Wang, J, Bachtiar, M, Chong, S.S, Lee, C.G.L
Other Authors:	DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
Format:	Article
Published:	2020
Subjects:	ABC transporter cytochrome P450 histone microRNA RNA splicing factor transcription factor allele amino acid sequence Article conserved sequence drug response drug transporter gene frameshift mutation gene gene deletion gene expression regulation gene frequency gene structure gene targeting genetic code genetic conservation genetic variability genotype environment interaction human human genome immune response immunogenetics indel mutation major histocompatibility complex natural selection population differentiation positive selection protein function protein structure purifying selection regulator gene single nucleotide polymorphism amino acid substitution genetic selection genetics innate immunity regulatory sequence RNA splicing Alleles Amino Acid Substitution Genome, Human Humans Immunity, Innate INDEL Mutation MicroRNAs Polymorphism, Single Nucleotide Regulatory Sequences, Nucleic Acid RNA Splicing Selection, Genetic
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/176210
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Institution:	National University of Singapore

id	sg-nus-scholar.10635-176210
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spelling	sg-nus-scholar.10635-1762102024-04-24T06:52:13Z Architecture of polymorphisms in the human genome reveals functionally important and positively selected variants in immune response and drug transporter genes Jin, Y Wang, J Bachtiar, M Chong, S.S Lee, C.G.L DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL) BIOCHEMISTRY PAEDIATRICS ABC transporter cytochrome P450 histone microRNA RNA splicing factor transcription factor microRNA allele amino acid sequence Article conserved sequence drug response drug transporter gene frameshift mutation gene gene deletion gene expression regulation gene frequency gene structure gene targeting genetic code genetic conservation genetic variability genotype environment interaction human human genome immune response immunogenetics indel mutation major histocompatibility complex natural selection population differentiation positive selection protein function protein structure purifying selection regulator gene single nucleotide polymorphism amino acid substitution genetic selection genetics human genome innate immunity regulatory sequence RNA splicing single nucleotide polymorphism Alleles Amino Acid Substitution Genome, Human Humans Immunity, Innate INDEL Mutation MicroRNAs Polymorphism, Single Nucleotide Regulatory Sequences, Nucleic Acid RNA Splicing Selection, Genetic 10.1186/s40246-018-0175-1 Human Genomics 12 1 43 2020-09-14T08:30:22Z 2020-09-14T08:30:22Z 2018 Article Jin, Y, Wang, J, Bachtiar, M, Chong, S.S, Lee, C.G.L (2018). Architecture of polymorphisms in the human genome reveals functionally important and positively selected variants in immune response and drug transporter genes. Human Genomics 12 (1) : 43. ScholarBank@NUS Repository. https://doi.org/10.1186/s40246-018-0175-1 1473-9542 https://scholarbank.nus.edu.sg/handle/10635/176210 Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	ABC transporter cytochrome P450 histone microRNA RNA splicing factor transcription factor microRNA allele amino acid sequence Article conserved sequence drug response drug transporter gene frameshift mutation gene gene deletion gene expression regulation gene frequency gene structure gene targeting genetic code genetic conservation genetic variability genotype environment interaction human human genome immune response immunogenetics indel mutation major histocompatibility complex natural selection population differentiation positive selection protein function protein structure purifying selection regulator gene single nucleotide polymorphism amino acid substitution genetic selection genetics human genome innate immunity regulatory sequence RNA splicing single nucleotide polymorphism Alleles Amino Acid Substitution Genome, Human Humans Immunity, Innate INDEL Mutation MicroRNAs Polymorphism, Single Nucleotide Regulatory Sequences, Nucleic Acid RNA Splicing Selection, Genetic
spellingShingle	ABC transporter cytochrome P450 histone microRNA RNA splicing factor transcription factor microRNA allele amino acid sequence Article conserved sequence drug response drug transporter gene frameshift mutation gene gene deletion gene expression regulation gene frequency gene structure gene targeting genetic code genetic conservation genetic variability genotype environment interaction human human genome immune response immunogenetics indel mutation major histocompatibility complex natural selection population differentiation positive selection protein function protein structure purifying selection regulator gene single nucleotide polymorphism amino acid substitution genetic selection genetics human genome innate immunity regulatory sequence RNA splicing single nucleotide polymorphism Alleles Amino Acid Substitution Genome, Human Humans Immunity, Innate INDEL Mutation MicroRNAs Polymorphism, Single Nucleotide Regulatory Sequences, Nucleic Acid RNA Splicing Selection, Genetic Jin, Y Wang, J Bachtiar, M Chong, S.S Lee, C.G.L Architecture of polymorphisms in the human genome reveals functionally important and positively selected variants in immune response and drug transporter genes
description	10.1186/s40246-018-0175-1
author2	DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
author_facet	DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL) Jin, Y Wang, J Bachtiar, M Chong, S.S Lee, C.G.L
format	Article
author	Jin, Y Wang, J Bachtiar, M Chong, S.S Lee, C.G.L
author_sort	Jin, Y
title	Architecture of polymorphisms in the human genome reveals functionally important and positively selected variants in immune response and drug transporter genes
title_short	Architecture of polymorphisms in the human genome reveals functionally important and positively selected variants in immune response and drug transporter genes
title_full	Architecture of polymorphisms in the human genome reveals functionally important and positively selected variants in immune response and drug transporter genes
title_fullStr	Architecture of polymorphisms in the human genome reveals functionally important and positively selected variants in immune response and drug transporter genes
title_full_unstemmed	Architecture of polymorphisms in the human genome reveals functionally important and positively selected variants in immune response and drug transporter genes
title_sort	architecture of polymorphisms in the human genome reveals functionally important and positively selected variants in immune response and drug transporter genes
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/176210
_version_	1800914421473607680

Architecture of polymorphisms in the human genome reveals functionally important and positively selected variants in immune response and drug transporter genes

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