Architecture of polymorphisms in the human genome reveals functionally important and positively selected variants in immune response and drug transporter genes

• Main Authors: Jin, Y, Wang, J, Bachtiar, M, Chong, S.S, Lee, C.G.L
• Other Authors: DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
• Format: Article
• Published: 2020
• Subjects: ABC transporter; cytochrome P450; histone; microRNA; RNA splicing factor; transcription factor; allele; amino acid sequence; Article; conserved sequence; drug response; drug transporter gene; frameshift mutation; gene; gene deletion; gene expression regulation; gene frequency; gene structure; gene targeting; genetic code; genetic conservation; genetic variability; genotype environment interaction; human; human genome; immune response; immunogenetics; indel mutation; major histocompatibility complex; natural selection; population differentiation; positive selection; protein function; protein structure; purifying selection; regulator gene; single nucleotide polymorphism; amino acid substitution; genetic selection; genetics; innate immunity; regulatory sequence; RNA splicing; Alleles; Amino Acid Substitution; Genome, Human; Humans; Immunity, Innate; INDEL Mutation; MicroRNAs; Polymorphism, Single Nucleotide; Regulatory Sequences, Nucleic Acid; RNA Splicing; Selection, Genetic
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/176210
• Institution: National University of Singapore

10.1186/s40246-018-0175-1