Wheel running from a juvenile age delays onset of specific motor deficits but does not alter protein aggregate density in a mouse model of Huntington's disease

• Main Authors: Van Dellen, A, Cordery, P.M, Spires, T.L, Blakemore, C, Hannan, A.J
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2020
• Subjects: huntingtin; HD protein, human; nerve protein; nuclear protein; age; animal experiment; animal model; animal tissue; article; brain weight; cingulate gyrus; controlled study; corpus striatum; environmental enrichment; exercise; exploratory behavior; female; habituation; Huntington chorea; locomotion; male; motor coordination; motor dysfunction; mouse; neuroprotection; nonhuman; open field test; physical activity; protein aggregation; rotarod test; running; sensory stimulation; aging; animal; atrophy; brain; cell inclusion; disease course; disease model; environmental planning; genetics; kinesiotherapy; metabolism; methodology; motor activity; pathology; pathophysiology; transgenic mouse; Aging; Animals; Atrophy; Brain; Disease Models, Animal; Disease Progression; Environment Design; Exercise Therapy; Exploratory Behavior; Female; Huntington Disease; Inclusion Bodies; Male; Mice; Mice, Transgenic; Motor Activity; Nerve Tissue Proteins; Nuclear Proteins; Physical Conditioning, Animal
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/177978
• Institution: National University of Singapore

10.1186/1471-2202-9-34