Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-? pathway and reveal microRNA regulation of TGFBR2

• Main Authors: Schultz, N, Marenstein, D.R, De Angelis, D.A, Wang, W.-Q, Nelander, S, Jacobsen, A, Marks, D.S, Massagué, J, Sander, C
• Other Authors: DEPT OF COMPUTER SCIENCE
• Format: Article
• Published: BMC 2020
• Subjects: green fluorescent protein; microRNA; microRNA 20a; microRNA 34a; microRNA 373; Smad2 protein; small interfering RNA; transforming growth factor beta; transforming growth factor beta receptor 1; transforming growth factor beta receptor 2; unclassified drug; 3' untranslated region; article; CDKN1A gene; cell proliferation; cell survival; controlled study; gene; gene identification; gene sequence; gene targeting; gene translocation; genetic analysis; genetic regulation; genetic screening; genetic transcription; human; human cell; keratinocyte; nuclear localization signal; open reading frame; PAI 1 gene; phenotype; priority journal; protein expression; protein phosphorylation; protein targeting; RNA interference; sequence analysis; signal transduction; SMAD7 gene; TGFBR1 gene; TGFBR2 gene
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178179
• Institution: National University of Singapore

10.1186/1758-907X-2-3