Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-? pathway and reveal microRNA regulation of TGFBR2
10.1186/1758-907X-2-3
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2020
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sg-nus-scholar.10635-1781792020-12-04T09:35:43Z Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-? pathway and reveal microRNA regulation of TGFBR2 Schultz, N Marenstein, D.R De Angelis, D.A Wang, W.-Q Nelander, S Jacobsen, A Marks, D.S Massagué, J Sander, C DEPT OF COMPUTER SCIENCE green fluorescent protein microRNA microRNA 20a microRNA 34a microRNA 373 Smad2 protein small interfering RNA transforming growth factor beta transforming growth factor beta receptor 1 transforming growth factor beta receptor 2 unclassified drug 3' untranslated region article CDKN1A gene cell proliferation cell survival controlled study gene gene identification gene sequence gene targeting gene translocation genetic analysis genetic regulation genetic screening genetic transcription human human cell keratinocyte nuclear localization signal open reading frame PAI 1 gene phenotype priority journal protein expression protein phosphorylation protein targeting RNA interference sequence analysis signal transduction SMAD7 gene TGFBR1 gene TGFBR2 gene 10.1186/1758-907X-2-3 Silence 2 1 3 2020-10-20T08:14:17Z 2020-10-20T08:14:17Z 2011 Article Schultz, N, Marenstein, D.R, De Angelis, D.A, Wang, W.-Q, Nelander, S, Jacobsen, A, Marks, D.S, Massagué, J, Sander, C (2011). Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-? pathway and reveal microRNA regulation of TGFBR2. Silence 2 (1) : 3. ScholarBank@NUS Repository. https://doi.org/10.1186/1758-907X-2-3 1758-907X https://scholarbank.nus.edu.sg/handle/10635/178179 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ BMC Unpaywall 20201031 |
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| topic |
green fluorescent protein microRNA microRNA 20a microRNA 34a microRNA 373 Smad2 protein small interfering RNA transforming growth factor beta transforming growth factor beta receptor 1 transforming growth factor beta receptor 2 unclassified drug 3' untranslated region article CDKN1A gene cell proliferation cell survival controlled study gene gene identification gene sequence gene targeting gene translocation genetic analysis genetic regulation genetic screening genetic transcription human human cell keratinocyte nuclear localization signal open reading frame PAI 1 gene phenotype priority journal protein expression protein phosphorylation protein targeting RNA interference sequence analysis signal transduction SMAD7 gene TGFBR1 gene TGFBR2 gene |
| spellingShingle |
green fluorescent protein microRNA microRNA 20a microRNA 34a microRNA 373 Smad2 protein small interfering RNA transforming growth factor beta transforming growth factor beta receptor 1 transforming growth factor beta receptor 2 unclassified drug 3' untranslated region article CDKN1A gene cell proliferation cell survival controlled study gene gene identification gene sequence gene targeting gene translocation genetic analysis genetic regulation genetic screening genetic transcription human human cell keratinocyte nuclear localization signal open reading frame PAI 1 gene phenotype priority journal protein expression protein phosphorylation protein targeting RNA interference sequence analysis signal transduction SMAD7 gene TGFBR1 gene TGFBR2 gene Schultz, N Marenstein, D.R De Angelis, D.A Wang, W.-Q Nelander, S Jacobsen, A Marks, D.S Massagué, J Sander, C Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-? pathway and reveal microRNA regulation of TGFBR2 |
| description |
10.1186/1758-907X-2-3 |
| author2 |
DEPT OF COMPUTER SCIENCE |
| author_facet |
DEPT OF COMPUTER SCIENCE Schultz, N Marenstein, D.R De Angelis, D.A Wang, W.-Q Nelander, S Jacobsen, A Marks, D.S Massagué, J Sander, C |
| format |
Article |
| author |
Schultz, N Marenstein, D.R De Angelis, D.A Wang, W.-Q Nelander, S Jacobsen, A Marks, D.S Massagué, J Sander, C |
| author_sort |
Schultz, N |
| title |
Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-? pathway and reveal microRNA regulation of TGFBR2 |
| title_short |
Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-? pathway and reveal microRNA regulation of TGFBR2 |
| title_full |
Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-? pathway and reveal microRNA regulation of TGFBR2 |
| title_fullStr |
Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-? pathway and reveal microRNA regulation of TGFBR2 |
| title_full_unstemmed |
Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-? pathway and reveal microRNA regulation of TGFBR2 |
| title_sort |
off-target effects dominate a large-scale rnai screen for modulators of the tgf-? pathway and reveal microrna regulation of tgfbr2 |
| publisher |
BMC |
| publishDate |
2020 |
| url |
https://scholarbank.nus.edu.sg/handle/10635/178179 |
| _version_ |
1686108971596775424 |