Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone

• Main Authors: Li, X.-F, Dong, H.-L, Wang, H.-J, Huang, X.-Y, Qiu, Y.-F, Ji, X, Ye, Q, Li, C, Liu, Y, Deng, Y.-Q, Jiang, T, Cheng, G, Zhang, F.-C, Davidson, A.D, Song, Y.-J, Shi, P.-Y, Qin, C.-F
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: epidermal growth factor receptor; gamma interferon; gamma interferon inducible protein 10; granulocyte macrophage colony stimulating factor; immunoglobulin G; interleukin 10; interleukin 15; interleukin 1beta; interleukin 2; interleukin 8; Japanese encephalitis vaccine; live vaccine; macrophage inflammatory protein 1beta; macrophage migration inhibition factor; monocyte chemotactic protein 1; neutralizing antibody; RANTES; sa 14 14 2; virus RNA; Zika virus vaccine; recombinant vaccine; virus antibody; virus vaccine; encephalitis; gene expression; genetic analysis; immune response; immunization; phenotype; protein; vaccine; Zika virus disease; animal experiment; animal model; animal tissue; antibody blood level; Article; cellular immunity; controlled study; cytokine production; drug efficacy; female; genetic stability; in vitro study; in vivo study; infection prevention; male; mouse; nonhuman; protein blood level; rhesus monkey; single drug dose; vaccination; vaccine immunogenicity; virus attenuation; Zika fever; 129 mouse; Aedes; animal; Bagg albino mouse; biosynthesis; disease model; genetic engineering; genetics; human; immunology; Japanese encephalitis virus; mosquito vector; pregnancy; prevention and control; vertical transmission; viremia; virology; Zika virus; Animalia; Flavivirus; Macaca mulatta; Mus; Animals; Antibodies, Neutralizing; Antibodies, Viral; Disease Models, Animal; Encephalitis Virus, Japanese; Female; Genetic Engineering; Humans; Infectious Disease Transmission, Vertical; Male; Mice; Mice, 129 Strain; Mice, Inbred BALB C; Mosquito Vectors; Pregnancy; Vaccines, Attenuated; Vaccines, Synthetic; Viral Vaccines; Viremia; Zika Virus; Zika Virus Infection
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178453
• Institution: National University of Singapore

10.1038/s41467-018-02975-w