Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone

10.1038/s41467-018-02975-w

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Main Authors:	Li, X.-F, Dong, H.-L, Wang, H.-J, Huang, X.-Y, Qiu, Y.-F, Ji, X, Ye, Q, Li, C, Liu, Y, Deng, Y.-Q, Jiang, T, Cheng, G, Zhang, F.-C, Davidson, A.D, Song, Y.-J, Shi, P.-Y, Qin, C.-F
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	epidermal growth factor receptor gamma interferon gamma interferon inducible protein 10 granulocyte macrophage colony stimulating factor immunoglobulin G interleukin 10 interleukin 15 interleukin 1beta interleukin 2 interleukin 8 Japanese encephalitis vaccine live vaccine macrophage inflammatory protein 1beta macrophage migration inhibition factor monocyte chemotactic protein 1 neutralizing antibody RANTES sa 14 14 2 virus RNA Zika virus vaccine recombinant vaccine virus antibody virus vaccine encephalitis gene expression genetic analysis immune response immunization phenotype protein vaccine Zika virus disease animal experiment animal model animal tissue antibody blood level Article cellular immunity controlled study cytokine production drug efficacy female genetic stability in vitro study in vivo study infection prevention male mouse nonhuman protein blood level rhesus monkey single drug dose vaccination vaccine immunogenicity virus attenuation Zika fever 129 mouse Aedes animal Bagg albino mouse biosynthesis disease model genetic engineering genetics human immunology Japanese encephalitis virus mosquito vector pregnancy prevention and control vertical transmission viremia virology Zika virus Animalia Flavivirus Macaca mulatta Mus Animals Antibodies, Neutralizing Antibodies, Viral Disease Models, Animal Encephalitis Virus, Japanese Female Genetic Engineering Humans Infectious Disease Transmission, Vertical Male Mice Mice, 129 Strain Mice, Inbred BALB C Mosquito Vectors Pregnancy Vaccines, Attenuated Vaccines, Synthetic Viral Vaccines Viremia Zika Virus Zika Virus Infection
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/178453
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1784532023-08-29T09:29:15Z Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone Li, X.-F Dong, H.-L Wang, H.-J Huang, X.-Y Qiu, Y.-F Ji, X Ye, Q Li, C Liu, Y Deng, Y.-Q Jiang, T Cheng, G Zhang, F.-C Davidson, A.D Song, Y.-J Shi, P.-Y Qin, C.-F DUKE-NUS MEDICAL SCHOOL epidermal growth factor receptor gamma interferon gamma interferon inducible protein 10 granulocyte macrophage colony stimulating factor immunoglobulin G interleukin 10 interleukin 15 interleukin 1beta interleukin 2 interleukin 8 Japanese encephalitis vaccine live vaccine macrophage inflammatory protein 1beta macrophage migration inhibition factor monocyte chemotactic protein 1 neutralizing antibody RANTES sa 14 14 2 virus RNA Zika virus vaccine live vaccine neutralizing antibody recombinant vaccine virus antibody virus vaccine encephalitis gene expression genetic analysis immune response immunization phenotype protein vaccine Zika virus disease animal experiment animal model animal tissue antibody blood level Article cellular immunity controlled study cytokine production drug efficacy female genetic stability in vitro study in vivo study infection prevention male mouse nonhuman protein blood level rhesus monkey single drug dose vaccination vaccine immunogenicity virus attenuation Zika fever 129 mouse Aedes animal Bagg albino mouse biosynthesis disease model genetic engineering genetics human immunology Japanese encephalitis virus mosquito vector pregnancy prevention and control vertical transmission viremia virology Zika fever Zika virus Animalia Flavivirus Japanese encephalitis virus Macaca mulatta Mus Zika virus Aedes Animals Antibodies, Neutralizing Antibodies, Viral Disease Models, Animal Encephalitis Virus, Japanese Female Genetic Engineering Humans Infectious Disease Transmission, Vertical Macaca mulatta Male Mice Mice, 129 Strain Mice, Inbred BALB C Mosquito Vectors Pregnancy Vaccines, Attenuated Vaccines, Synthetic Viral Vaccines Viremia Zika Virus Zika Virus Infection 10.1038/s41467-018-02975-w Nature Communications 9 1 673 2020-10-20T09:58:38Z 2020-10-20T09:58:38Z 2018 Article Li, X.-F, Dong, H.-L, Wang, H.-J, Huang, X.-Y, Qiu, Y.-F, Ji, X, Ye, Q, Li, C, Liu, Y, Deng, Y.-Q, Jiang, T, Cheng, G, Zhang, F.-C, Davidson, A.D, Song, Y.-J, Shi, P.-Y, Qin, C.-F (2018). Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone. Nature Communications 9 (1) : 673. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-018-02975-w 2041-1723 https://scholarbank.nus.edu.sg/handle/10635/178453 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Nature Publishing Group Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	epidermal growth factor receptor gamma interferon gamma interferon inducible protein 10 granulocyte macrophage colony stimulating factor immunoglobulin G interleukin 10 interleukin 15 interleukin 1beta interleukin 2 interleukin 8 Japanese encephalitis vaccine live vaccine macrophage inflammatory protein 1beta macrophage migration inhibition factor monocyte chemotactic protein 1 neutralizing antibody RANTES sa 14 14 2 virus RNA Zika virus vaccine live vaccine neutralizing antibody recombinant vaccine virus antibody virus vaccine encephalitis gene expression genetic analysis immune response immunization phenotype protein vaccine Zika virus disease animal experiment animal model animal tissue antibody blood level Article cellular immunity controlled study cytokine production drug efficacy female genetic stability in vitro study in vivo study infection prevention male mouse nonhuman protein blood level rhesus monkey single drug dose vaccination vaccine immunogenicity virus attenuation Zika fever 129 mouse Aedes animal Bagg albino mouse biosynthesis disease model genetic engineering genetics human immunology Japanese encephalitis virus mosquito vector pregnancy prevention and control vertical transmission viremia virology Zika fever Zika virus Animalia Flavivirus Japanese encephalitis virus Macaca mulatta Mus Zika virus Aedes Animals Antibodies, Neutralizing Antibodies, Viral Disease Models, Animal Encephalitis Virus, Japanese Female Genetic Engineering Humans Infectious Disease Transmission, Vertical Macaca mulatta Male Mice Mice, 129 Strain Mice, Inbred BALB C Mosquito Vectors Pregnancy Vaccines, Attenuated Vaccines, Synthetic Viral Vaccines Viremia Zika Virus Zika Virus Infection
spellingShingle	epidermal growth factor receptor gamma interferon gamma interferon inducible protein 10 granulocyte macrophage colony stimulating factor immunoglobulin G interleukin 10 interleukin 15 interleukin 1beta interleukin 2 interleukin 8 Japanese encephalitis vaccine live vaccine macrophage inflammatory protein 1beta macrophage migration inhibition factor monocyte chemotactic protein 1 neutralizing antibody RANTES sa 14 14 2 virus RNA Zika virus vaccine live vaccine neutralizing antibody recombinant vaccine virus antibody virus vaccine encephalitis gene expression genetic analysis immune response immunization phenotype protein vaccine Zika virus disease animal experiment animal model animal tissue antibody blood level Article cellular immunity controlled study cytokine production drug efficacy female genetic stability in vitro study in vivo study infection prevention male mouse nonhuman protein blood level rhesus monkey single drug dose vaccination vaccine immunogenicity virus attenuation Zika fever 129 mouse Aedes animal Bagg albino mouse biosynthesis disease model genetic engineering genetics human immunology Japanese encephalitis virus mosquito vector pregnancy prevention and control vertical transmission viremia virology Zika fever Zika virus Animalia Flavivirus Japanese encephalitis virus Macaca mulatta Mus Zika virus Aedes Animals Antibodies, Neutralizing Antibodies, Viral Disease Models, Animal Encephalitis Virus, Japanese Female Genetic Engineering Humans Infectious Disease Transmission, Vertical Macaca mulatta Male Mice Mice, 129 Strain Mice, Inbred BALB C Mosquito Vectors Pregnancy Vaccines, Attenuated Vaccines, Synthetic Viral Vaccines Viremia Zika Virus Zika Virus Infection Li, X.-F Dong, H.-L Wang, H.-J Huang, X.-Y Qiu, Y.-F Ji, X Ye, Q Li, C Liu, Y Deng, Y.-Q Jiang, T Cheng, G Zhang, F.-C Davidson, A.D Song, Y.-J Shi, P.-Y Qin, C.-F Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone
description	10.1038/s41467-018-02975-w
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Li, X.-F Dong, H.-L Wang, H.-J Huang, X.-Y Qiu, Y.-F Ji, X Ye, Q Li, C Liu, Y Deng, Y.-Q Jiang, T Cheng, G Zhang, F.-C Davidson, A.D Song, Y.-J Shi, P.-Y Qin, C.-F
format	Article
author	Li, X.-F Dong, H.-L Wang, H.-J Huang, X.-Y Qiu, Y.-F Ji, X Ye, Q Li, C Liu, Y Deng, Y.-Q Jiang, T Cheng, G Zhang, F.-C Davidson, A.D Song, Y.-J Shi, P.-Y Qin, C.-F
author_sort	Li, X.-F
title	Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone
title_short	Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone
title_full	Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone
title_fullStr	Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone
title_full_unstemmed	Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone
title_sort	development of a chimeric zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/178453
_version_	1779152295583285248

Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone

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