Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing

10.1038/s41467-017-02584-z

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Main Authors:	Nahar, R, Zhai, W, Zhang, T, Takano, A, Khng, A.J, Lee, Y.Y, Liu, X, Lim, C.H, Koh, T.P.T, Aung, Z.W, Lim, T.K.H, Veeravalli, L, Yuan, J, Teo, A.S.M, Chan, C.X, Poh, H.M, Chua, I.M.L, Liew, A.A, Lau, D.P.X, Kwang, X.L, Toh, C.K, Lim, W.-T, Lim, B, Tam, W.L, Tan, E.-H, Hillmer, A.M, Tan, D.S.W
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	apolipoprotein B mRNA editing enzyme catalytic polypeptide like cyclin dependent kinase inhibitor 2A epidermal growth factor receptor protein p53 protein tyrosine kinase inhibitor protein kinase inhibitor cell clone comparative study drug resistance gene genome inhibitor molecular analysis mutation protein tumor animal cell animal tissue Article Asian carcinogenesis cell cycle regulation cell disruption clinical article controlled study copy number variation enzyme activity gene amplification gene deletion gene mutation genetic background genetic heterogeneity genomic instability human human cell human tissue lung adenocarcinoma molecular cloning mouse nonhuman RB1 gene single nucleotide polymorphism smoking whole exome sequencing adenocarcinoma Asian continental ancestry group drug effects ethnology genetic predisposition genetics genomics lung tumor pathology procedures tumor cell line Adenocarcinoma Asian Continental Ancestry Group Cell Line, Tumor Drug Resistance, Neoplasm Genetic Predisposition to Disease Genomics Humans Lung Neoplasms Mutation Protein Kinase Inhibitors Receptor, Epidermal Growth Factor Whole Exome Sequencing
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/178527
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1785272024-04-22T03:33:44Z Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing Nahar, R Zhai, W Zhang, T Takano, A Khng, A.J Lee, Y.Y Liu, X Lim, C.H Koh, T.P.T Aung, Z.W Lim, T.K.H Veeravalli, L Yuan, J Teo, A.S.M Chan, C.X Poh, H.M Chua, I.M.L Liew, A.A Lau, D.P.X Kwang, X.L Toh, C.K Lim, W.-T Lim, B Tam, W.L Tan, E.-H Hillmer, A.M Tan, D.S.W DUKE-NUS MEDICAL SCHOOL BIOCHEMISTRY apolipoprotein B mRNA editing enzyme catalytic polypeptide like cyclin dependent kinase inhibitor 2A epidermal growth factor receptor protein p53 protein tyrosine kinase inhibitor epidermal growth factor receptor protein kinase inhibitor cell clone comparative study drug resistance gene genome inhibitor molecular analysis mutation protein tumor animal cell animal tissue Article Asian carcinogenesis cell cycle regulation cell disruption clinical article controlled study copy number variation enzyme activity gene gene amplification gene deletion gene mutation genetic background genetic heterogeneity genomic instability human human cell human tissue lung adenocarcinoma molecular cloning mouse nonhuman RB1 gene single nucleotide polymorphism smoking whole exome sequencing adenocarcinoma Asian continental ancestry group drug effects drug resistance ethnology genetic predisposition genetics genomics lung tumor mutation pathology procedures tumor cell line whole exome sequencing Adenocarcinoma Asian Continental Ancestry Group Cell Line, Tumor Drug Resistance, Neoplasm Genetic Predisposition to Disease Genomics Humans Lung Neoplasms Mutation Protein Kinase Inhibitors Receptor, Epidermal Growth Factor Whole Exome Sequencing 10.1038/s41467-017-02584-z Nature Communications 9 1 216 2020-10-20T10:10:21Z 2020-10-20T10:10:21Z 2018 Article Nahar, R, Zhai, W, Zhang, T, Takano, A, Khng, A.J, Lee, Y.Y, Liu, X, Lim, C.H, Koh, T.P.T, Aung, Z.W, Lim, T.K.H, Veeravalli, L, Yuan, J, Teo, A.S.M, Chan, C.X, Poh, H.M, Chua, I.M.L, Liew, A.A, Lau, D.P.X, Kwang, X.L, Toh, C.K, Lim, W.-T, Lim, B, Tam, W.L, Tan, E.-H, Hillmer, A.M, Tan, D.S.W (2018). Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing. Nature Communications 9 (1) : 216. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-017-02584-z 2041-1723 https://scholarbank.nus.edu.sg/handle/10635/178527 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Nature Publishing Group Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	apolipoprotein B mRNA editing enzyme catalytic polypeptide like cyclin dependent kinase inhibitor 2A epidermal growth factor receptor protein p53 protein tyrosine kinase inhibitor epidermal growth factor receptor protein kinase inhibitor cell clone comparative study drug resistance gene genome inhibitor molecular analysis mutation protein tumor animal cell animal tissue Article Asian carcinogenesis cell cycle regulation cell disruption clinical article controlled study copy number variation enzyme activity gene gene amplification gene deletion gene mutation genetic background genetic heterogeneity genomic instability human human cell human tissue lung adenocarcinoma molecular cloning mouse nonhuman RB1 gene single nucleotide polymorphism smoking whole exome sequencing adenocarcinoma Asian continental ancestry group drug effects drug resistance ethnology genetic predisposition genetics genomics lung tumor mutation pathology procedures tumor cell line whole exome sequencing Adenocarcinoma Asian Continental Ancestry Group Cell Line, Tumor Drug Resistance, Neoplasm Genetic Predisposition to Disease Genomics Humans Lung Neoplasms Mutation Protein Kinase Inhibitors Receptor, Epidermal Growth Factor Whole Exome Sequencing
spellingShingle	apolipoprotein B mRNA editing enzyme catalytic polypeptide like cyclin dependent kinase inhibitor 2A epidermal growth factor receptor protein p53 protein tyrosine kinase inhibitor epidermal growth factor receptor protein kinase inhibitor cell clone comparative study drug resistance gene genome inhibitor molecular analysis mutation protein tumor animal cell animal tissue Article Asian carcinogenesis cell cycle regulation cell disruption clinical article controlled study copy number variation enzyme activity gene gene amplification gene deletion gene mutation genetic background genetic heterogeneity genomic instability human human cell human tissue lung adenocarcinoma molecular cloning mouse nonhuman RB1 gene single nucleotide polymorphism smoking whole exome sequencing adenocarcinoma Asian continental ancestry group drug effects drug resistance ethnology genetic predisposition genetics genomics lung tumor mutation pathology procedures tumor cell line whole exome sequencing Adenocarcinoma Asian Continental Ancestry Group Cell Line, Tumor Drug Resistance, Neoplasm Genetic Predisposition to Disease Genomics Humans Lung Neoplasms Mutation Protein Kinase Inhibitors Receptor, Epidermal Growth Factor Whole Exome Sequencing Nahar, R Zhai, W Zhang, T Takano, A Khng, A.J Lee, Y.Y Liu, X Lim, C.H Koh, T.P.T Aung, Z.W Lim, T.K.H Veeravalli, L Yuan, J Teo, A.S.M Chan, C.X Poh, H.M Chua, I.M.L Liew, A.A Lau, D.P.X Kwang, X.L Toh, C.K Lim, W.-T Lim, B Tam, W.L Tan, E.-H Hillmer, A.M Tan, D.S.W Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing
description	10.1038/s41467-017-02584-z
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Nahar, R Zhai, W Zhang, T Takano, A Khng, A.J Lee, Y.Y Liu, X Lim, C.H Koh, T.P.T Aung, Z.W Lim, T.K.H Veeravalli, L Yuan, J Teo, A.S.M Chan, C.X Poh, H.M Chua, I.M.L Liew, A.A Lau, D.P.X Kwang, X.L Toh, C.K Lim, W.-T Lim, B Tam, W.L Tan, E.-H Hillmer, A.M Tan, D.S.W
format	Article
author	Nahar, R Zhai, W Zhang, T Takano, A Khng, A.J Lee, Y.Y Liu, X Lim, C.H Koh, T.P.T Aung, Z.W Lim, T.K.H Veeravalli, L Yuan, J Teo, A.S.M Chan, C.X Poh, H.M Chua, I.M.L Liew, A.A Lau, D.P.X Kwang, X.L Toh, C.K Lim, W.-T Lim, B Tam, W.L Tan, E.-H Hillmer, A.M Tan, D.S.W
author_sort	Nahar, R
title	Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing
title_short	Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing
title_full	Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing
title_fullStr	Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing
title_full_unstemmed	Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing
title_sort	elucidating the genomic architecture of asian egfr-mutant lung adenocarcinoma through multi-region exome sequencing
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/178527
_version_	1800914506490052608

Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing

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