Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing

• Main Authors: Nahar, R, Zhai, W, Zhang, T, Takano, A, Khng, A.J, Lee, Y.Y, Liu, X, Lim, C.H, Koh, T.P.T, Aung, Z.W, Lim, T.K.H, Veeravalli, L, Yuan, J, Teo, A.S.M, Chan, C.X, Poh, H.M, Chua, I.M.L, Liew, A.A, Lau, D.P.X, Kwang, X.L, Toh, C.K, Lim, W.-T, Lim, B, Tam, W.L, Tan, E.-H, Hillmer, A.M, Tan, D.S.W
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: apolipoprotein B mRNA editing enzyme catalytic polypeptide like; cyclin dependent kinase inhibitor 2A; epidermal growth factor receptor; protein p53; protein tyrosine kinase inhibitor; protein kinase inhibitor; cell; clone; comparative study; drug resistance; gene; genome; inhibitor; molecular analysis; mutation; protein; tumor; animal cell; animal tissue; Article; Asian; carcinogenesis; cell cycle regulation; cell disruption; clinical article; controlled study; copy number variation; enzyme activity; gene amplification; gene deletion; gene mutation; genetic background; genetic heterogeneity; genomic instability; human; human cell; human tissue; lung adenocarcinoma; molecular cloning; mouse; nonhuman; RB1 gene; single nucleotide polymorphism; smoking; whole exome sequencing; adenocarcinoma; Asian continental ancestry group; drug effects; ethnology; genetic predisposition; genetics; genomics; lung tumor; pathology; procedures; tumor cell line; Adenocarcinoma; Asian Continental Ancestry Group; Cell Line, Tumor; Drug Resistance, Neoplasm; Genetic Predisposition to Disease; Genomics; Humans; Lung Neoplasms; Mutation; Protein Kinase Inhibitors; Receptor, Epidermal Growth Factor; Whole Exome Sequencing
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178527
• Institution: National University of Singapore

10.1038/s41467-017-02584-z