Rap1 deficiency-provoked paracrine dysfunction impairs immunosuppressive potency of mesenchymal stem cells in allograft rejection of heart transplantation

• Main Authors: Ding, Y, Liang, X, Zhang, Y, Yi, L, Shum, H.C, Chen, Q, Chan, B.P, Fan, H, Liu, Z, Tergaonkar, V, Qi, Z, Tse, H.-F, Lian, Q
• Other Authors: PATHOLOGY
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: immunoglobulin enhancer binding protein; Rap1 protein; rapamycin; acute graft rejection; animal experiment; Article; cell encapsulation; controlled study; cytokine production; cytokine release; down regulation; gene construct; graft recipient; graft survival; heart transplantation; immunomodulation; in vitro study; mesenchymal stem cell; mixed lymphocyte reaction; mouse; nonhuman; paracrine signaling; priority journal; regulatory mechanism; adverse event; allograft; animal; Bagg albino mouse; C57BL mouse; cell culture; cell proliferation; genetics; graft rejection; knockout mouse; metabolism; physiology; Western blotting; Allografts; Animals; Blotting, Western; Cell Proliferation; Cells, Cultured; Graft Rejection; Heart Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; rap1 GTP-Binding Proteins
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178536
• Institution: National University of Singapore

10.1038/s41419-018-0414-3