Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time

10.1038/s41467-017-00451-5

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Main Authors:	Chia, S, Low, J.-L, Zhang, X, Kwang, X.-L, Chong, F.-T, Sharma, A, Bertrand, D, Toh, S.Y, Leong, H.-S, Thangavelu, M.T, Hwang, J.S.G, Lim, K.-H, Skanthakumar, T, Tan, H.-K, Su, Y, Hui Choo, S, Hentze, H, Tan, I.B.H, Lezhava, A, Tan, P, Tan, D.S.W, Periyasamy, G, Koh, J.L.Y, Gopalakrishna Iyer, N, Dasgupta, R
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	antineoplastic agent belinostat biological marker cisplatin cytotoxic agent docetaxol epithelial cell adhesion molecule erlotinib flavopiridol gefitinib olaparib protein tyrosine kinase inhibitor sepantronium bromide survivin transcription factor Yap1 unclassified drug uvomorulin phosphoprotein quinazoline derivative signal transducing adaptor protein tumor marker YAP1 (Yes-associated) protein, human biomarker cancer cells and cell components genetic analysis phenotype survival tumor accuracy animal experiment animal model Article cancer genetics cancer growth cancer resistance cancer survival case study cell culture cell proliferation cell viability clinical article clinical decision making clinical practice coculture disease free survival drug repositioning drug substitution drug withdrawal epithelial mesenchymal transition esophageal adenocarcinoma gene expression head and neck squamous cell carcinoma human IC50 immunohistochemistry in vitro study lymph node metastasis monotherapy mouth squamous cell carcinoma nonhuman overall survival primary culture protein expression protein protein interaction rat short tandem repeat treatment indication treatment response tumor-related gene unspecified side effect upregulation animal drug resistance drug screening gene expression regulation genetics head and neck tumor mouth tumor nonobese diabetic mouse pathology personalized medicine procedures squamous cell carcinoma treatment outcome tumor cell culture Adaptor Proteins, Signal Transducing Animals Biomarkers, Tumor Carcinoma, Squamous Cell Cisplatin Drug Resistance, Neoplasm Gene Expression Regulation, Neoplastic Head and Neck Neoplasms Humans Mice, Inbred NOD Mouth Neoplasms Phenotype Phosphoproteins Precision Medicine Quinazolines Treatment Outcome Tumor Cells, Cultured Xenograft Model Antitumor Assays
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/178584
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1785842023-08-30T22:08:49Z Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time Chia, S Low, J.-L Zhang, X Kwang, X.-L Chong, F.-T Sharma, A Bertrand, D Toh, S.Y Leong, H.-S Thangavelu, M.T Hwang, J.S.G Lim, K.-H Skanthakumar, T Tan, H.-K Su, Y Hui Choo, S Hentze, H Tan, I.B.H Lezhava, A Tan, P Tan, D.S.W Periyasamy, G Koh, J.L.Y Gopalakrishna Iyer, N Dasgupta, R DUKE-NUS MEDICAL SCHOOL antineoplastic agent belinostat biological marker cisplatin cytotoxic agent docetaxol epithelial cell adhesion molecule erlotinib flavopiridol gefitinib olaparib protein tyrosine kinase inhibitor sepantronium bromide survivin transcription factor Yap1 unclassified drug uvomorulin cisplatin phosphoprotein quinazoline derivative signal transducing adaptor protein tumor marker YAP1 (Yes-associated) protein, human biomarker cancer cells and cell components genetic analysis phenotype survival tumor accuracy animal experiment animal model Article cancer genetics cancer growth cancer resistance cancer survival case study cell culture cell proliferation cell viability clinical article clinical decision making clinical practice coculture disease free survival drug repositioning drug substitution drug withdrawal epithelial mesenchymal transition esophageal adenocarcinoma gene expression head and neck squamous cell carcinoma human IC50 immunohistochemistry in vitro study lymph node metastasis monotherapy mouth squamous cell carcinoma nonhuman overall survival phenotype primary culture protein expression protein protein interaction rat short tandem repeat treatment indication treatment response tumor-related gene unspecified side effect upregulation animal drug resistance drug screening gene expression regulation genetics head and neck tumor mouth tumor nonobese diabetic mouse pathology personalized medicine phenotype procedures squamous cell carcinoma treatment outcome tumor cell culture Adaptor Proteins, Signal Transducing Animals Biomarkers, Tumor Carcinoma, Squamous Cell Cisplatin Drug Resistance, Neoplasm Gene Expression Regulation, Neoplastic Head and Neck Neoplasms Humans Mice, Inbred NOD Mouth Neoplasms Phenotype Phosphoproteins Precision Medicine Quinazolines Treatment Outcome Tumor Cells, Cultured Xenograft Model Antitumor Assays 10.1038/s41467-017-00451-5 Nature Communications 8 1 435 2020-10-20T10:25:51Z 2020-10-20T10:25:51Z 2017 Article Chia, S, Low, J.-L, Zhang, X, Kwang, X.-L, Chong, F.-T, Sharma, A, Bertrand, D, Toh, S.Y, Leong, H.-S, Thangavelu, M.T, Hwang, J.S.G, Lim, K.-H, Skanthakumar, T, Tan, H.-K, Su, Y, Hui Choo, S, Hentze, H, Tan, I.B.H, Lezhava, A, Tan, P, Tan, D.S.W, Periyasamy, G, Koh, J.L.Y, Gopalakrishna Iyer, N, Dasgupta, R (2017). Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time. Nature Communications 8 (1) : 435. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-017-00451-5 2041-1723 https://scholarbank.nus.edu.sg/handle/10635/178584 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Nature Publishing Group Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	antineoplastic agent belinostat biological marker cisplatin cytotoxic agent docetaxol epithelial cell adhesion molecule erlotinib flavopiridol gefitinib olaparib protein tyrosine kinase inhibitor sepantronium bromide survivin transcription factor Yap1 unclassified drug uvomorulin cisplatin phosphoprotein quinazoline derivative signal transducing adaptor protein tumor marker YAP1 (Yes-associated) protein, human biomarker cancer cells and cell components genetic analysis phenotype survival tumor accuracy animal experiment animal model Article cancer genetics cancer growth cancer resistance cancer survival case study cell culture cell proliferation cell viability clinical article clinical decision making clinical practice coculture disease free survival drug repositioning drug substitution drug withdrawal epithelial mesenchymal transition esophageal adenocarcinoma gene expression head and neck squamous cell carcinoma human IC50 immunohistochemistry in vitro study lymph node metastasis monotherapy mouth squamous cell carcinoma nonhuman overall survival phenotype primary culture protein expression protein protein interaction rat short tandem repeat treatment indication treatment response tumor-related gene unspecified side effect upregulation animal drug resistance drug screening gene expression regulation genetics head and neck tumor mouth tumor nonobese diabetic mouse pathology personalized medicine phenotype procedures squamous cell carcinoma treatment outcome tumor cell culture Adaptor Proteins, Signal Transducing Animals Biomarkers, Tumor Carcinoma, Squamous Cell Cisplatin Drug Resistance, Neoplasm Gene Expression Regulation, Neoplastic Head and Neck Neoplasms Humans Mice, Inbred NOD Mouth Neoplasms Phenotype Phosphoproteins Precision Medicine Quinazolines Treatment Outcome Tumor Cells, Cultured Xenograft Model Antitumor Assays
spellingShingle	antineoplastic agent belinostat biological marker cisplatin cytotoxic agent docetaxol epithelial cell adhesion molecule erlotinib flavopiridol gefitinib olaparib protein tyrosine kinase inhibitor sepantronium bromide survivin transcription factor Yap1 unclassified drug uvomorulin cisplatin phosphoprotein quinazoline derivative signal transducing adaptor protein tumor marker YAP1 (Yes-associated) protein, human biomarker cancer cells and cell components genetic analysis phenotype survival tumor accuracy animal experiment animal model Article cancer genetics cancer growth cancer resistance cancer survival case study cell culture cell proliferation cell viability clinical article clinical decision making clinical practice coculture disease free survival drug repositioning drug substitution drug withdrawal epithelial mesenchymal transition esophageal adenocarcinoma gene expression head and neck squamous cell carcinoma human IC50 immunohistochemistry in vitro study lymph node metastasis monotherapy mouth squamous cell carcinoma nonhuman overall survival phenotype primary culture protein expression protein protein interaction rat short tandem repeat treatment indication treatment response tumor-related gene unspecified side effect upregulation animal drug resistance drug screening gene expression regulation genetics head and neck tumor mouth tumor nonobese diabetic mouse pathology personalized medicine phenotype procedures squamous cell carcinoma treatment outcome tumor cell culture Adaptor Proteins, Signal Transducing Animals Biomarkers, Tumor Carcinoma, Squamous Cell Cisplatin Drug Resistance, Neoplasm Gene Expression Regulation, Neoplastic Head and Neck Neoplasms Humans Mice, Inbred NOD Mouth Neoplasms Phenotype Phosphoproteins Precision Medicine Quinazolines Treatment Outcome Tumor Cells, Cultured Xenograft Model Antitumor Assays Chia, S Low, J.-L Zhang, X Kwang, X.-L Chong, F.-T Sharma, A Bertrand, D Toh, S.Y Leong, H.-S Thangavelu, M.T Hwang, J.S.G Lim, K.-H Skanthakumar, T Tan, H.-K Su, Y Hui Choo, S Hentze, H Tan, I.B.H Lezhava, A Tan, P Tan, D.S.W Periyasamy, G Koh, J.L.Y Gopalakrishna Iyer, N Dasgupta, R Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time
description	10.1038/s41467-017-00451-5
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Chia, S Low, J.-L Zhang, X Kwang, X.-L Chong, F.-T Sharma, A Bertrand, D Toh, S.Y Leong, H.-S Thangavelu, M.T Hwang, J.S.G Lim, K.-H Skanthakumar, T Tan, H.-K Su, Y Hui Choo, S Hentze, H Tan, I.B.H Lezhava, A Tan, P Tan, D.S.W Periyasamy, G Koh, J.L.Y Gopalakrishna Iyer, N Dasgupta, R
format	Article
author	Chia, S Low, J.-L Zhang, X Kwang, X.-L Chong, F.-T Sharma, A Bertrand, D Toh, S.Y Leong, H.-S Thangavelu, M.T Hwang, J.S.G Lim, K.-H Skanthakumar, T Tan, H.-K Su, Y Hui Choo, S Hentze, H Tan, I.B.H Lezhava, A Tan, P Tan, D.S.W Periyasamy, G Koh, J.L.Y Gopalakrishna Iyer, N Dasgupta, R
author_sort	Chia, S
title	Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time
title_short	Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time
title_full	Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time
title_fullStr	Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time
title_full_unstemmed	Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time
title_sort	phenotype-driven precision oncology as a guide for clinical decisions one patient at a time
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/178584
_version_	1779152323267788800

Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time

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