Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time

• Main Authors: Chia, S, Low, J.-L, Zhang, X, Kwang, X.-L, Chong, F.-T, Sharma, A, Bertrand, D, Toh, S.Y, Leong, H.-S, Thangavelu, M.T, Hwang, J.S.G, Lim, K.-H, Skanthakumar, T, Tan, H.-K, Su, Y, Hui Choo, S, Hentze, H, Tan, I.B.H, Lezhava, A, Tan, P, Tan, D.S.W, Periyasamy, G, Koh, J.L.Y, Gopalakrishna Iyer, N, Dasgupta, R
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: antineoplastic agent; belinostat; biological marker; cisplatin; cytotoxic agent; docetaxol; epithelial cell adhesion molecule; erlotinib; flavopiridol; gefitinib; olaparib; protein tyrosine kinase inhibitor; sepantronium bromide; survivin; transcription factor Yap1; unclassified drug; uvomorulin; phosphoprotein; quinazoline derivative; signal transducing adaptor protein; tumor marker; YAP1 (Yes-associated) protein, human; biomarker; cancer; cells and cell components; genetic analysis; phenotype; survival; tumor; accuracy; animal experiment; animal model; Article; cancer genetics; cancer growth; cancer resistance; cancer survival; case study; cell culture; cell proliferation; cell viability; clinical article; clinical decision making; clinical practice; coculture; disease free survival; drug repositioning; drug substitution; drug withdrawal; epithelial mesenchymal transition; esophageal adenocarcinoma; gene expression; head and neck squamous cell carcinoma; human; IC50; immunohistochemistry; in vitro study; lymph node metastasis; monotherapy; mouth squamous cell carcinoma; nonhuman; overall survival; primary culture; protein expression; protein protein interaction; rat; short tandem repeat; treatment indication; treatment response; tumor-related gene; unspecified side effect; upregulation; animal; drug resistance; drug screening; gene expression regulation; genetics; head and neck tumor; mouth tumor; nonobese diabetic mouse; pathology; personalized medicine; procedures; squamous cell carcinoma; treatment outcome; tumor cell culture; Adaptor Proteins, Signal Transducing; Animals; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cisplatin; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; Mice, Inbred NOD; Mouth Neoplasms; Phenotype; Phosphoproteins; Precision Medicine; Quinazolines; Treatment Outcome; Tumor Cells, Cultured; Xenograft Model Antitumor Assays
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178584
• Institution: National University of Singapore

10.1038/s41467-017-00451-5