Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo

• Main Authors: See, K, Tan, W.L.W, Lim, E.H, Tiang, Z, Lee, L.T, Li, P.Y.Q, Luu, T.D.A, Ackers-Johnson, M, Foo, R.S
• Other Authors: MEDICINE
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: alpha actinin 2; CD34 antigen; cyclin G1; homeobox protein Nkx-2.5; long untranslated RNA; nuclear RNA; stem cell antigen 1; vasculotropin receptor 2; GAS5 long non-coding RNA, human; NODAL protein, human; protein Nodal; transcriptome; cardiovascular disease; cells and cell components; genetic analysis; genetic differentiation; heterogeneity; laboratory method; RNA; rodent; adult; animal cell; animal experiment; animal tissue; Article; cardiac muscle cell; Ccnd2 gene; cell cycle; cell dedifferentiation; cell stress; cell subpopulation; controlled study; Dstn gene; gene; gene expression; gene regulatory network; gene silencing; Hand2 gene; heart failure; heart left ventricle; human; human cell; human tissue; in vivo study; male; Mef2a gene; Mef2c gene; mouse; Msn gene; nonhuman; RNA sequence; upregulation; animal; C57BL mouse; cytology; gene expression regulation; genetics; metabolism; pathophysiology; physiological stress; Mammalia; Animals; Cell Cycle; Cell Dedifferentiation; Gene Expression Regulation; Gene Regulatory Networks; Heart Failure; Humans; Male; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Nodal Protein; RNA, Long Noncoding; Stress, Physiological; Transcriptome
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178594
• Institution: National University of Singapore

10.1038/s41467-017-00319-8