Disruption of the C/EBP? - MiR-182 balance impairs granulocytic differentiation

• Main Authors: Wurm, A.A, Zjablovskaja, P, Kardosova, M, Gerloff, D, Bräuer-Hartmann, D, Katzerke, C, Hartmann, J.-U, Benoukraf, T, Fricke, S, Hilger, N, Müller, A.-M, Bill, M, Schwind, S, Tenen, D.G, Niederwieser, D, Alberich-Jorda, M, Behre, G
• Other Authors: CANCER SCIENCE INSTITUTE OF SINGAPORE
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: CCAAT enhancer binding protein alpha; microRNA 182; CCAAT enhancer binding protein; CEBPA protein, human; CEBPA protein, mouse; microRNA; Mirn182 microRNA, human; Mirn182 microRNA, mouse; biological development; cancer; chemical binding; gene expression; genetic analysis; genetic marker; laboratory method; mutation; protein; acute myeloid leukemia; animal cell; animal experiment; animal model; animal tissue; Article; bone marrow cell; carboxy terminal sequence; cell differentiation; controlled study; downstream processing; gene disruption; gene mutation; gene targeting; granulocyte; granulopoiesis; human; human cell; in vitro study; in vivo study; mouse; nonhuman; oncogene; promoter region; animal; genetics; knockout mouse; leukopoiesis; metabolism; mortality; prognosis; real time polymerase chain reaction; Western blotting; Animals; Blotting, Western; CCAAT-Enhancer-Binding Proteins; Cell Differentiation; Granulocytes; Humans; Leukemia, Myeloid, Acute; Leukopoiesis; Mice; Mice, Knockout; MicroRNAs; Prognosis; Real-Time Polymerase Chain Reaction
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178606
• Institution: National University of Singapore

10.1038/s41467-017-00032-6