In vivo and in vitro activities and ADME-tox profile of a quinolizidine-modified 4-aminoquinoline: A potent anti-P. falciparum and Anti-P. vivax blood-stage antimalarial

10.3390/molecules22122102

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Bibliographic Details
Main Authors:	Basilico, N, Parapini, S, Sparatore, A, Romeo, S, Misiano, P, Vivas, L, Yardley, V, Croft, S.L, Habluetzel, A, Lucantoni, L, Renia, L, Russell, B, Suwanarusk, R, Nosten, F, Dondio, G, Bigogno, C, Jabes, D, Taramelli, D
Other Authors:	MICROBIOLOGY AND IMMUNOLOGY
Format:	Article
Published:	MDPI AG 2020
Subjects:	aminoquinoline derivative antimalarial agent artemisinin artemisinin derivative chloroquine lupinine quinolizidine derivative sparteine analogs and derivatives animal chemistry drug effect drug resistance HEK293 cell line human IC50 malaria male mouse parasitemia Plasmodium falciparum Plasmodium vivax Aminoquinolines Animals Antimalarials Artemisinins Chloroquine Drug Resistance HEK293 Cells Humans Inhibitory Concentration 50 Malaria Male Mice Parasitemia Quinolizidines Sparteine
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/179070
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Institution:	National University of Singapore

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Summary:	10.3390/molecules22122102