In vivo and in vitro activities and ADME-tox profile of a quinolizidine-modified 4-aminoquinoline: A potent anti-P. falciparum and Anti-P. vivax blood-stage antimalarial

• Main Authors: Basilico, N, Parapini, S, Sparatore, A, Romeo, S, Misiano, P, Vivas, L, Yardley, V, Croft, S.L, Habluetzel, A, Lucantoni, L, Renia, L, Russell, B, Suwanarusk, R, Nosten, F, Dondio, G, Bigogno, C, Jabes, D, Taramelli, D
• Other Authors: MICROBIOLOGY AND IMMUNOLOGY
• Format: Article
• Published: MDPI AG 2020
• Subjects: aminoquinoline derivative; antimalarial agent; artemisinin; artemisinin derivative; chloroquine; lupinine; quinolizidine derivative; sparteine; analogs and derivatives; animal; chemistry; drug effect; drug resistance; HEK293 cell line; human; IC50; malaria; male; mouse; parasitemia; Plasmodium falciparum; Plasmodium vivax; Aminoquinolines; Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; HEK293 Cells; Humans; Inhibitory Concentration 50; Malaria; Male; Mice; Parasitemia; Quinolizidines; Sparteine
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179070
• Institution: National University of Singapore

10.3390/molecules22122102