Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity

• Main Authors: Thomas, D.C, Clare, S, Sowerby, J.M, Pardo, M, Juss, J.K, Goulding, D.A, van der Weyden, L, Storisteanu, D, Prakash, A, Espéli, M, Flint, S, Lee, J.C, Hoenderdos, K, Kane, L, Harcourt, K, Mukhopadhyay, S, Umrania, Y, Antrobus, R, Nathan, J.A, Adams, D.J, Bateman, A, Choudhary, J.S, Lyons, P.A, Condliffe, A.M, Chilvers, E.R, Dougan, G, Smith, K.G.C
• Other Authors: MEDICINE
• Format: Article
• Published: Rockefeller University Press 2020
• Subjects: cytochrome b558; essential for reactive oxygen species; glycoprotein gp 91; interleukin 10; interleukin 12p70; interleukin 6; membrane protein; plant protein; protein p22; protein p40; protein p47; protein p67; proteome; Rac protein; reactive oxygen metabolite; reduced nicotinamide adenine dinucleotide phosphate oxidase; tumor necrosis factor; unclassified drug; Ycf4 protein; Cybb protein, mouse; cytochrome b; Eros protein, mouse; p22(phox) protein, mouse; animal cell; animal experiment; animal model; animal tissue; Article; Citrobacter rodentium; citrobacter rodentium infection; comparative study; controlled study; Enterobacteriaceae infection; extracellular trap; female; host resistance; human; human cell; infection risk; innate immunity; macrophage; metastatic melanoma; mouse; neutrophil; nonhuman; normal human; orthology; phagocyte; photosynthesis; photosystem I; priority journal; protein expression; protein function; respiratory burst; Salmonella enterica serovar Typhimurium; tumor immunity; typhoid fever; animal; C57BL mouse; endoplasmic reticulum; HEK293 cell line; immunology; metabolism; phagocytosis; physiology; Animals; Cytochrome b Group; Endoplasmic Reticulum; HEK293 Cells; Humans; Immunity, Innate; Macrophages; Membrane Glycoproteins; Membrane Proteins; Mice; Mice, Inbred C57BL; NADPH Oxidase; Neutrophils; Phagocytes; Phagocytosis; Reactive Oxygen Species; Respiratory Burst
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179211
• Institution: National University of Singapore

10.1084/jem.20161382