BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity

10.15252/emmm.201607446

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Main Authors:	Tacconi, E.M.C, Lai, X, Folio, C, Porru, M, Zonderland, G, Badie, S, Michl, J, Sechi, I, Rogier, M, Matía García, V, Batra, A.S, Rueda, O.M, Bouwman, P, Jonkers, J, Ryan, A, Reina-San-Martin, B, Hui, J, Tang, N, Bruna, A, Biroccio, A, Tarsounas, M
Other Authors:	CANCER SCIENCE INSTITUTE OF SINGAPORE
Format:	Article
Published:	2020
Subjects:	acetaldehyde BRCA1 protein BRCA2 protein disulfiram nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor Rad51 protein aldehyde dehydrogenase isoenzyme 2 ALDH2 protein, human BRCA1 protein, human BRCA2 protein, human FANCD2 protein, human Fanconi anemia group D2 protein RAD51 protein, human alcoholism animal cell animal experiment animal model Article bioaccumulation cancer inhibition cell cycle progression cell death cell proliferation cell survival cell viability controlled study CRISPR-CAS9 system DNA damage DNA damage checkpoint enzyme metabolism female fluorescence activated cell sorting G2 phase cell cycle checkpoint human human cell human tissue male mouse nonhuman priority journal protein function protein targeting quantitative analysis real time polymerase chain reaction recombination repair RNA interference animal drug screening Fanconi anemia fibroblast genetics homologous recombination metabolism nude mouse tumor cell line Acetaldehyde Aldehyde Dehydrogenase, Mitochondrial Animals BRCA1 Protein BRCA2 Protein Cell Line, Tumor DNA Damage Fanconi Anemia Fanconi Anemia Complementation Group D2 Protein Fibroblasts Homologous Recombination Humans Mice Mice, Nude Rad51 Recombinase Xenograft Model Antitumor Assays
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/179456
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1794562023-08-07T09:36:02Z BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity Tacconi, E.M.C Lai, X Folio, C Porru, M Zonderland, G Badie, S Michl, J Sechi, I Rogier, M Matía García, V Batra, A.S Rueda, O.M Bouwman, P Jonkers, J Ryan, A Reina-San-Martin, B Hui, J Tang, N Bruna, A Biroccio, A Tarsounas, M CANCER SCIENCE INSTITUTE OF SINGAPORE acetaldehyde BRCA1 protein BRCA2 protein disulfiram nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor Rad51 protein acetaldehyde aldehyde dehydrogenase isoenzyme 2 ALDH2 protein, human BRCA1 protein BRCA1 protein, human BRCA2 protein BRCA2 protein, human FANCD2 protein, human Fanconi anemia group D2 protein Rad51 protein RAD51 protein, human alcoholism animal cell animal experiment animal model Article bioaccumulation cancer inhibition cell cycle progression cell death cell proliferation cell survival cell viability controlled study CRISPR-CAS9 system DNA damage DNA damage checkpoint enzyme metabolism female fluorescence activated cell sorting G2 phase cell cycle checkpoint human human cell human tissue male mouse nonhuman priority journal protein function protein targeting quantitative analysis real time polymerase chain reaction recombination repair RNA interference animal drug screening Fanconi anemia fibroblast genetics homologous recombination metabolism nude mouse tumor cell line Acetaldehyde Aldehyde Dehydrogenase, Mitochondrial Animals BRCA1 Protein BRCA2 Protein Cell Line, Tumor DNA Damage Fanconi Anemia Fanconi Anemia Complementation Group D2 Protein Fibroblasts Homologous Recombination Humans Mice Mice, Nude Rad51 Recombinase Xenograft Model Antitumor Assays 10.15252/emmm.201607446 EMBO Molecular Medicine 9 10 1398-1414 2020-10-23T04:39:24Z 2020-10-23T04:39:24Z 2017 Article Tacconi, E.M.C, Lai, X, Folio, C, Porru, M, Zonderland, G, Badie, S, Michl, J, Sechi, I, Rogier, M, Matía García, V, Batra, A.S, Rueda, O.M, Bouwman, P, Jonkers, J, Ryan, A, Reina-San-Martin, B, Hui, J, Tang, N, Bruna, A, Biroccio, A, Tarsounas, M (2017). BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity. EMBO Molecular Medicine 9 (10) : 1398-1414. ScholarBank@NUS Repository. https://doi.org/10.15252/emmm.201607446 17574676 https://scholarbank.nus.edu.sg/handle/10635/179456 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	acetaldehyde BRCA1 protein BRCA2 protein disulfiram nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor Rad51 protein acetaldehyde aldehyde dehydrogenase isoenzyme 2 ALDH2 protein, human BRCA1 protein BRCA1 protein, human BRCA2 protein BRCA2 protein, human FANCD2 protein, human Fanconi anemia group D2 protein Rad51 protein RAD51 protein, human alcoholism animal cell animal experiment animal model Article bioaccumulation cancer inhibition cell cycle progression cell death cell proliferation cell survival cell viability controlled study CRISPR-CAS9 system DNA damage DNA damage checkpoint enzyme metabolism female fluorescence activated cell sorting G2 phase cell cycle checkpoint human human cell human tissue male mouse nonhuman priority journal protein function protein targeting quantitative analysis real time polymerase chain reaction recombination repair RNA interference animal drug screening Fanconi anemia fibroblast genetics homologous recombination metabolism nude mouse tumor cell line Acetaldehyde Aldehyde Dehydrogenase, Mitochondrial Animals BRCA1 Protein BRCA2 Protein Cell Line, Tumor DNA Damage Fanconi Anemia Fanconi Anemia Complementation Group D2 Protein Fibroblasts Homologous Recombination Humans Mice Mice, Nude Rad51 Recombinase Xenograft Model Antitumor Assays
spellingShingle	acetaldehyde BRCA1 protein BRCA2 protein disulfiram nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor Rad51 protein acetaldehyde aldehyde dehydrogenase isoenzyme 2 ALDH2 protein, human BRCA1 protein BRCA1 protein, human BRCA2 protein BRCA2 protein, human FANCD2 protein, human Fanconi anemia group D2 protein Rad51 protein RAD51 protein, human alcoholism animal cell animal experiment animal model Article bioaccumulation cancer inhibition cell cycle progression cell death cell proliferation cell survival cell viability controlled study CRISPR-CAS9 system DNA damage DNA damage checkpoint enzyme metabolism female fluorescence activated cell sorting G2 phase cell cycle checkpoint human human cell human tissue male mouse nonhuman priority journal protein function protein targeting quantitative analysis real time polymerase chain reaction recombination repair RNA interference animal drug screening Fanconi anemia fibroblast genetics homologous recombination metabolism nude mouse tumor cell line Acetaldehyde Aldehyde Dehydrogenase, Mitochondrial Animals BRCA1 Protein BRCA2 Protein Cell Line, Tumor DNA Damage Fanconi Anemia Fanconi Anemia Complementation Group D2 Protein Fibroblasts Homologous Recombination Humans Mice Mice, Nude Rad51 Recombinase Xenograft Model Antitumor Assays Tacconi, E.M.C Lai, X Folio, C Porru, M Zonderland, G Badie, S Michl, J Sechi, I Rogier, M Matía García, V Batra, A.S Rueda, O.M Bouwman, P Jonkers, J Ryan, A Reina-San-Martin, B Hui, J Tang, N Bruna, A Biroccio, A Tarsounas, M BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity
description	10.15252/emmm.201607446
author2	CANCER SCIENCE INSTITUTE OF SINGAPORE
author_facet	CANCER SCIENCE INSTITUTE OF SINGAPORE Tacconi, E.M.C Lai, X Folio, C Porru, M Zonderland, G Badie, S Michl, J Sechi, I Rogier, M Matía García, V Batra, A.S Rueda, O.M Bouwman, P Jonkers, J Ryan, A Reina-San-Martin, B Hui, J Tang, N Bruna, A Biroccio, A Tarsounas, M
format	Article
author	Tacconi, E.M.C Lai, X Folio, C Porru, M Zonderland, G Badie, S Michl, J Sechi, I Rogier, M Matía García, V Batra, A.S Rueda, O.M Bouwman, P Jonkers, J Ryan, A Reina-San-Martin, B Hui, J Tang, N Bruna, A Biroccio, A Tarsounas, M
author_sort	Tacconi, E.M.C
title	BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity
title_short	BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity
title_full	BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity
title_fullStr	BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity
title_full_unstemmed	BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity
title_sort	brca1 and brca2 tumor suppressors protect against endogenous acetaldehyde toxicity
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/179456
_version_	1779152466344935424

BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity

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