BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity

• Main Authors: Tacconi, E.M.C, Lai, X, Folio, C, Porru, M, Zonderland, G, Badie, S, Michl, J, Sechi, I, Rogier, M, Matía García, V, Batra, A.S, Rueda, O.M, Bouwman, P, Jonkers, J, Ryan, A, Reina-San-Martin, B, Hui, J, Tang, N, Bruna, A, Biroccio, A, Tarsounas, M
• Other Authors: CANCER SCIENCE INSTITUTE OF SINGAPORE
• Format: Article
• Published: 2020
• Subjects: acetaldehyde; BRCA1 protein; BRCA2 protein; disulfiram; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor; Rad51 protein; aldehyde dehydrogenase isoenzyme 2; ALDH2 protein, human; BRCA1 protein, human; BRCA2 protein, human; FANCD2 protein, human; Fanconi anemia group D2 protein; RAD51 protein, human; alcoholism; animal cell; animal experiment; animal model; Article; bioaccumulation; cancer inhibition; cell cycle progression; cell death; cell proliferation; cell survival; cell viability; controlled study; CRISPR-CAS9 system; DNA damage; DNA damage checkpoint; enzyme metabolism; female; fluorescence activated cell sorting; G2 phase cell cycle checkpoint; human; human cell; human tissue; male; mouse; nonhuman; priority journal; protein function; protein targeting; quantitative analysis; real time polymerase chain reaction; recombination repair; RNA interference; animal; drug screening; Fanconi anemia; fibroblast; genetics; homologous recombination; metabolism; nude mouse; tumor cell line; Acetaldehyde; Aldehyde Dehydrogenase, Mitochondrial; Animals; BRCA1 Protein; BRCA2 Protein; Cell Line, Tumor; DNA Damage; Fanconi Anemia; Fanconi Anemia Complementation Group D2 Protein; Fibroblasts; Homologous Recombination; Humans; Mice; Mice, Nude; Rad51 Recombinase; Xenograft Model Antitumor Assays
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179456
• Institution: National University of Singapore

10.15252/emmm.201607446