Epigenetic reprogramming converts human Wharton's jelly mesenchymal stem cells into functional cardiomyocytes by differential regulation of Wnt mediators

• Main Authors: Bhuvanalakshmi, G, Arfuso, F, Kumar, A.P, Dharmarajan, A, Warrier, S
• Other Authors: DEPT OF PHARMACOLOGY
• Format: Article
• Published: 2020
• Subjects: calcium; DKK1 protein, human; DKK3 protein, human; homeobox protein Nkx-2.5; nitric oxide; NKX2-5 protein, human; oncoprotein; SFRP4 protein, human; signal peptide; Wnt protein; animal; antagonists and inhibitors; C57BL mouse; cardiac muscle; cardiac muscle cell; cell differentiation; cell separation; CpG island; cytology; DNA demethylation; fibrosis; genetic epigenesis; genetics; human; male; mesenchymal stroma cell; metabolism; nuclear reprogramming; nucleotide sequence; organogenesis; pathology; promoter region; transplantation; upregulation; Wharton jelly; Animals; Base Sequence; Calcium; Cell Differentiation; Cell Separation; Cellular Reprogramming; CpG Islands; DNA Demethylation; Epigenesis, Genetic; Fibrosis; Homeobox Protein Nkx-2.5; Humans; Intercellular Signaling Peptides and Proteins; Male; Mesenchymal Stromal Cells; Mice, Inbred C57BL; Myocardium; Myocytes, Cardiac; Nitric Oxide; Organogenesis; Promoter Regions, Genetic; Proto-Oncogene Proteins; Up-Regulation; Wharton Jelly; Wnt Proteins
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179465
• Institution: National University of Singapore

10.1186/s13287-017-0638-7