Natural killer cells from patients with recombinase-activating gene and non-homologous end joining gene defects comprise a higher frequency of CD56bright NKG2A+++ cells, and yet display increased degranulation and higher perforin content

• Main Authors: Dobbs, K|Tabellini, G, Calzoni, E
• Other Authors: PAEDIATRICS
• Format: Article
• Published: 2020
• Subjects: CD16 antigen; CD56 antigen; CD57 antigen; chemokine receptor CXCR1; gamma interferon; interleukin 10; interleukin 12; interleukin 18; killer cell immunoglobulin like receptor; natural killer cell receptor NKG2A; perforin; tumor necrosis factor; adolescent; adult; Article; child; controlled study; correlation analysis; cytomegalovirus infection; degranulation; Epstein Barr virus infection; female; fluorescence activated cell sorting; gene; gene frequency; gene mutation; herpes zoster; human; human cell; immunophenotyping; infant; lymphocyte proliferation; lymphocytopenia; major clinical study; male; natural killer cell; newborn; non homologous end joining gene; Omenn syndrome; protein expression; recombinase activating gene; severe combined immunodeficiency; T lymphocyte; X linked agammaglobulinemia
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179473
• Institution: National University of Singapore

10.3389/fimmu.2017.00798