Deep sequencing of influenza A virus from a human challenge study reveals a selective bottleneck and only limited intrahost genetic diversification

• Main Authors: Leonard, A.S, McClain, M.T, Smith, G.J.D, Wentworth, D.E, Halpin, R.A, Lin, X, Ransier, A, Stockwell, T.B, Das, S.R, Gilbert, A.S, Lambkin-Williams, R, Ginsburg, G.S, Woods, C.W, Koelle, K
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: American Society for Microbiology 2020
• Subjects: virus hemagglutinin; virus nucleoprotein; virus RNA; Article; controlled study; disease course; genetic distance; genetic variation; human; human experiment; Influenza A virus; Influenza A virus (H3N2); inoculation; molecular evolution; nasal lavage fluid; next generation sequencing; nonhuman; normal human; priority journal; quantitative analysis; virus gene; animal; biological model; chicken; genetic selection; genetics; growth, development and aging; high throughput sequencing; influenza; virology; virus genome; zygote; Animals; Chickens; Evolution, Molecular; Genetic Variation; Genome, Viral; High-Throughput Nucleotide Sequencing; Humans; Influenza A Virus, H3N2 Subtype; Influenza, Human; Models, Genetic; RNA, Viral; Selection, Genetic; Zygote
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179610
• Institution: National University of Singapore

10.1128/JVI.01657-16