Deep sequencing of influenza A virus from a human challenge study reveals a selective bottleneck and only limited intrahost genetic diversification

10.1128/JVI.01657-16

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Main Authors:	Leonard, A.S, McClain, M.T, Smith, G.J.D, Wentworth, D.E, Halpin, R.A, Lin, X, Ransier, A, Stockwell, T.B, Das, S.R, Gilbert, A.S, Lambkin-Williams, R, Ginsburg, G.S, Woods, C.W, Koelle, K
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	American Society for Microbiology 2020
Subjects:	virus hemagglutinin virus nucleoprotein virus RNA Article controlled study disease course genetic distance genetic variation human human experiment Influenza A virus Influenza A virus (H3N2) inoculation molecular evolution nasal lavage fluid next generation sequencing nonhuman normal human priority journal quantitative analysis virus gene animal biological model chicken genetic selection genetics growth, development and aging high throughput sequencing influenza virology virus genome zygote Animals Chickens Evolution, Molecular Genetic Variation Genome, Viral High-Throughput Nucleotide Sequencing Humans Influenza A Virus, H3N2 Subtype Influenza, Human Models, Genetic RNA, Viral Selection, Genetic Zygote
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/179610
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1796102024-11-09T20:13:09Z Deep sequencing of influenza A virus from a human challenge study reveals a selective bottleneck and only limited intrahost genetic diversification Leonard, A.S McClain, M.T Smith, G.J.D Wentworth, D.E Halpin, R.A Lin, X Ransier, A Stockwell, T.B Das, S.R Gilbert, A.S Lambkin-Williams, R Ginsburg, G.S Woods, C.W Koelle, K DUKE-NUS MEDICAL SCHOOL virus hemagglutinin virus nucleoprotein virus RNA Article controlled study disease course genetic distance genetic variation human human experiment Influenza A virus Influenza A virus (H3N2) inoculation molecular evolution nasal lavage fluid next generation sequencing nonhuman normal human priority journal quantitative analysis virus gene animal biological model chicken genetic selection genetic variation genetics growth, development and aging high throughput sequencing influenza virology virus genome zygote Animals Chickens Evolution, Molecular Genetic Variation Genome, Viral High-Throughput Nucleotide Sequencing Humans Influenza A Virus, H3N2 Subtype Influenza, Human Models, Genetic RNA, Viral Selection, Genetic Zygote 10.1128/JVI.01657-16 Journal of Virology 90 24 11247-11258 2020-10-23T08:02:48Z 2020-10-23T08:02:48Z 2016 Article Leonard, A.S, McClain, M.T, Smith, G.J.D, Wentworth, D.E, Halpin, R.A, Lin, X, Ransier, A, Stockwell, T.B, Das, S.R, Gilbert, A.S, Lambkin-Williams, R, Ginsburg, G.S, Woods, C.W, Koelle, K (2016). Deep sequencing of influenza A virus from a human challenge study reveals a selective bottleneck and only limited intrahost genetic diversification. Journal of Virology 90 (24) : 11247-11258. ScholarBank@NUS Repository. https://doi.org/10.1128/JVI.01657-16 0022-538X https://scholarbank.nus.edu.sg/handle/10635/179610 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ American Society for Microbiology Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	virus hemagglutinin virus nucleoprotein virus RNA Article controlled study disease course genetic distance genetic variation human human experiment Influenza A virus Influenza A virus (H3N2) inoculation molecular evolution nasal lavage fluid next generation sequencing nonhuman normal human priority journal quantitative analysis virus gene animal biological model chicken genetic selection genetic variation genetics growth, development and aging high throughput sequencing influenza virology virus genome zygote Animals Chickens Evolution, Molecular Genetic Variation Genome, Viral High-Throughput Nucleotide Sequencing Humans Influenza A Virus, H3N2 Subtype Influenza, Human Models, Genetic RNA, Viral Selection, Genetic Zygote
spellingShingle	virus hemagglutinin virus nucleoprotein virus RNA Article controlled study disease course genetic distance genetic variation human human experiment Influenza A virus Influenza A virus (H3N2) inoculation molecular evolution nasal lavage fluid next generation sequencing nonhuman normal human priority journal quantitative analysis virus gene animal biological model chicken genetic selection genetic variation genetics growth, development and aging high throughput sequencing influenza virology virus genome zygote Animals Chickens Evolution, Molecular Genetic Variation Genome, Viral High-Throughput Nucleotide Sequencing Humans Influenza A Virus, H3N2 Subtype Influenza, Human Models, Genetic RNA, Viral Selection, Genetic Zygote Leonard, A.S McClain, M.T Smith, G.J.D Wentworth, D.E Halpin, R.A Lin, X Ransier, A Stockwell, T.B Das, S.R Gilbert, A.S Lambkin-Williams, R Ginsburg, G.S Woods, C.W Koelle, K Deep sequencing of influenza A virus from a human challenge study reveals a selective bottleneck and only limited intrahost genetic diversification
description	10.1128/JVI.01657-16
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Leonard, A.S McClain, M.T Smith, G.J.D Wentworth, D.E Halpin, R.A Lin, X Ransier, A Stockwell, T.B Das, S.R Gilbert, A.S Lambkin-Williams, R Ginsburg, G.S Woods, C.W Koelle, K
format	Article
author	Leonard, A.S McClain, M.T Smith, G.J.D Wentworth, D.E Halpin, R.A Lin, X Ransier, A Stockwell, T.B Das, S.R Gilbert, A.S Lambkin-Williams, R Ginsburg, G.S Woods, C.W Koelle, K
author_sort	Leonard, A.S
title	Deep sequencing of influenza A virus from a human challenge study reveals a selective bottleneck and only limited intrahost genetic diversification
title_short	Deep sequencing of influenza A virus from a human challenge study reveals a selective bottleneck and only limited intrahost genetic diversification
title_full	Deep sequencing of influenza A virus from a human challenge study reveals a selective bottleneck and only limited intrahost genetic diversification
title_fullStr	Deep sequencing of influenza A virus from a human challenge study reveals a selective bottleneck and only limited intrahost genetic diversification
title_full_unstemmed	Deep sequencing of influenza A virus from a human challenge study reveals a selective bottleneck and only limited intrahost genetic diversification
title_sort	deep sequencing of influenza a virus from a human challenge study reveals a selective bottleneck and only limited intrahost genetic diversification
publisher	American Society for Microbiology
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/179610
_version_	1821219577412976640

Deep sequencing of influenza A virus from a human challenge study reveals a selective bottleneck and only limited intrahost genetic diversification

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