Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

• Main Authors: Willems, S.M, Wright, D.J, Day, F.R
• Other Authors: OBSTETRICS & GYNAECOLOGY
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: analytical method; biomechanics; fitness; gene; genetic analysis; genetic structure; genome; morbidity; mortality; muscle; ACTG1 gene; Article; female; gene locus; genome-wide association study; grip strength; hand grip; human; KANSL1 gene; LRPPRC gene; major clinical study; male; Mendelian randomization analysis; muscle cell; muscle strength; PEX14 gene; psychomotor disorder; signal transduction; skeletal muscle; SYT1 gene; TGFA gene; adult; aged; Caucasian; cohort analysis; genetics; hand; hand strength; middle aged; physiology; population genetics; single nucleotide polymorphism; United Kingdom; ACTG1 protein, human; actin; KANSL1 protein, human; LRPPRC protein, human; membrane protein; nuclear protein; PEX14 protein, human; repressor protein; TGFA protein, human; transforming growth factor alpha; tumor protein; Actins; Adult; Aged; Cohort Studies; European Continental Ancestry Group; Female; Genetic Loci; Genetics, Population; Genome-Wide Association Study; Hand; Hand Strength; Humans; Male; Membrane Proteins; Middle Aged; Neoplasm Proteins; Nuclear Proteins; Polymorphism, Single Nucleotide; Repressor Proteins; Transforming Growth Factor alpha
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179708
• Institution: National University of Singapore

10.1038/ncomms16015