Silencing NKG2D ligand-Targeting miRNAs enhances natural killer cell-mediated cytotoxicity in breast cancer

10.1038/cddis.2017.158

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Main Authors:	Shen, J, Pan, J, Du, C, Si, W, Yao, M, Xu, L, Zheng, H, Xu, M, Chen, D, Wang, S, Fu, P, Fan, W
Other Authors:	BIOLOGY (NU)
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	histone deacetylase inhibitor ligand MICA protein MICB protein microRNA microRNA 17 92 microRNA 20a microRNA 20b mitogen activated protein kinase natural killer cell receptor NKG2D ULBP1 protein ULBP2 protein ULBP3 protein unclassified drug KLRK1 protein, human MIRN20 microRNA, human natural killer cell lectin like receptor subfamily K RNA tumor protein 3' untranslated region animal experiment animal model antigen recognition Article BC cell line Bcap37 cell line binding site breast cancer breast tissue BT-474 cell line cancer patient cancer prognosis cancer staging cancer survival cancer tissue controlled study down regulation enzyme inhibition gene cluster gene silencing gene targeting HS 578T cell line human human tissue in vitro study in vivo study ligand binding male MAPK signaling MCF-7 cell line MDA-MB-231 cell line MDA-MB-468 cell line mouse natural killer cell mediated cytotoxicity nonhuman overall survival priority journal protein analysis protein expression protein function SK-BR-3 cell line tumor immunogenicity upregulation animal breast tumor drug effects female genetics immunology natural killer cell pathology Animals Breast Neoplasms Female Histone Deacetylase Inhibitors Humans Killer Cells, Natural Male MAP Kinase Signaling System MCF-7 Cells Mice MicroRNAs Neoplasm Proteins NK Cell Lectin-Like Receptor Subfamily K RNA, Neoplasm
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/179756
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1797562023-09-20T08:50:05Z Silencing NKG2D ligand-Targeting miRNAs enhances natural killer cell-mediated cytotoxicity in breast cancer Shen, J Pan, J Du, C Si, W Yao, M Xu, L Zheng, H Xu, M Chen, D Wang, S Fu, P Fan, W BIOLOGY (NU) histone deacetylase inhibitor ligand MICA protein MICB protein microRNA microRNA 17 92 microRNA 20a microRNA 20b mitogen activated protein kinase natural killer cell receptor NKG2D ULBP1 protein ULBP2 protein ULBP3 protein unclassified drug histone deacetylase inhibitor KLRK1 protein, human microRNA MIRN20 microRNA, human natural killer cell lectin like receptor subfamily K RNA tumor protein 3' untranslated region animal experiment animal model antigen recognition Article BC cell line Bcap37 cell line binding site breast cancer breast tissue BT-474 cell line cancer patient cancer prognosis cancer staging cancer survival cancer tissue controlled study down regulation enzyme inhibition gene cluster gene silencing gene targeting HS 578T cell line human human tissue in vitro study in vivo study ligand binding male MAPK signaling MCF-7 cell line MDA-MB-231 cell line MDA-MB-468 cell line mouse natural killer cell mediated cytotoxicity nonhuman overall survival priority journal protein analysis protein expression protein function SK-BR-3 cell line tumor immunogenicity upregulation animal breast tumor drug effects female genetics immunology natural killer cell pathology Animals Breast Neoplasms Female Histone Deacetylase Inhibitors Humans Killer Cells, Natural Male MAP Kinase Signaling System MCF-7 Cells Mice MicroRNAs Neoplasm Proteins NK Cell Lectin-Like Receptor Subfamily K RNA, Neoplasm 10.1038/cddis.2017.158 Cell Death and Disease 8 4 e2740 2020-10-26T02:57:20Z 2020-10-26T02:57:20Z 2017 Article Shen, J, Pan, J, Du, C, Si, W, Yao, M, Xu, L, Zheng, H, Xu, M, Chen, D, Wang, S, Fu, P, Fan, W (2017). Silencing NKG2D ligand-Targeting miRNAs enhances natural killer cell-mediated cytotoxicity in breast cancer. Cell Death and Disease 8 (4) : e2740. ScholarBank@NUS Repository. https://doi.org/10.1038/cddis.2017.158 2041-4889 https://scholarbank.nus.edu.sg/handle/10635/179756 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Nature Publishing Group Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	histone deacetylase inhibitor ligand MICA protein MICB protein microRNA microRNA 17 92 microRNA 20a microRNA 20b mitogen activated protein kinase natural killer cell receptor NKG2D ULBP1 protein ULBP2 protein ULBP3 protein unclassified drug histone deacetylase inhibitor KLRK1 protein, human microRNA MIRN20 microRNA, human natural killer cell lectin like receptor subfamily K RNA tumor protein 3' untranslated region animal experiment animal model antigen recognition Article BC cell line Bcap37 cell line binding site breast cancer breast tissue BT-474 cell line cancer patient cancer prognosis cancer staging cancer survival cancer tissue controlled study down regulation enzyme inhibition gene cluster gene silencing gene targeting HS 578T cell line human human tissue in vitro study in vivo study ligand binding male MAPK signaling MCF-7 cell line MDA-MB-231 cell line MDA-MB-468 cell line mouse natural killer cell mediated cytotoxicity nonhuman overall survival priority journal protein analysis protein expression protein function SK-BR-3 cell line tumor immunogenicity upregulation animal breast tumor drug effects female genetics immunology natural killer cell pathology Animals Breast Neoplasms Female Histone Deacetylase Inhibitors Humans Killer Cells, Natural Male MAP Kinase Signaling System MCF-7 Cells Mice MicroRNAs Neoplasm Proteins NK Cell Lectin-Like Receptor Subfamily K RNA, Neoplasm
spellingShingle	histone deacetylase inhibitor ligand MICA protein MICB protein microRNA microRNA 17 92 microRNA 20a microRNA 20b mitogen activated protein kinase natural killer cell receptor NKG2D ULBP1 protein ULBP2 protein ULBP3 protein unclassified drug histone deacetylase inhibitor KLRK1 protein, human microRNA MIRN20 microRNA, human natural killer cell lectin like receptor subfamily K RNA tumor protein 3' untranslated region animal experiment animal model antigen recognition Article BC cell line Bcap37 cell line binding site breast cancer breast tissue BT-474 cell line cancer patient cancer prognosis cancer staging cancer survival cancer tissue controlled study down regulation enzyme inhibition gene cluster gene silencing gene targeting HS 578T cell line human human tissue in vitro study in vivo study ligand binding male MAPK signaling MCF-7 cell line MDA-MB-231 cell line MDA-MB-468 cell line mouse natural killer cell mediated cytotoxicity nonhuman overall survival priority journal protein analysis protein expression protein function SK-BR-3 cell line tumor immunogenicity upregulation animal breast tumor drug effects female genetics immunology natural killer cell pathology Animals Breast Neoplasms Female Histone Deacetylase Inhibitors Humans Killer Cells, Natural Male MAP Kinase Signaling System MCF-7 Cells Mice MicroRNAs Neoplasm Proteins NK Cell Lectin-Like Receptor Subfamily K RNA, Neoplasm Shen, J Pan, J Du, C Si, W Yao, M Xu, L Zheng, H Xu, M Chen, D Wang, S Fu, P Fan, W Silencing NKG2D ligand-Targeting miRNAs enhances natural killer cell-mediated cytotoxicity in breast cancer
description	10.1038/cddis.2017.158
author2	BIOLOGY (NU)
author_facet	BIOLOGY (NU) Shen, J Pan, J Du, C Si, W Yao, M Xu, L Zheng, H Xu, M Chen, D Wang, S Fu, P Fan, W
format	Article
author	Shen, J Pan, J Du, C Si, W Yao, M Xu, L Zheng, H Xu, M Chen, D Wang, S Fu, P Fan, W
author_sort	Shen, J
title	Silencing NKG2D ligand-Targeting miRNAs enhances natural killer cell-mediated cytotoxicity in breast cancer
title_short	Silencing NKG2D ligand-Targeting miRNAs enhances natural killer cell-mediated cytotoxicity in breast cancer
title_full	Silencing NKG2D ligand-Targeting miRNAs enhances natural killer cell-mediated cytotoxicity in breast cancer
title_fullStr	Silencing NKG2D ligand-Targeting miRNAs enhances natural killer cell-mediated cytotoxicity in breast cancer
title_full_unstemmed	Silencing NKG2D ligand-Targeting miRNAs enhances natural killer cell-mediated cytotoxicity in breast cancer
title_sort	silencing nkg2d ligand-targeting mirnas enhances natural killer cell-mediated cytotoxicity in breast cancer
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/179756
_version_	1779152557737771008

Silencing NKG2D ligand-Targeting miRNAs enhances natural killer cell-mediated cytotoxicity in breast cancer

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