Silencing NKG2D ligand-Targeting miRNAs enhances natural killer cell-mediated cytotoxicity in breast cancer

• Main Authors: Shen, J, Pan, J, Du, C, Si, W, Yao, M, Xu, L, Zheng, H, Xu, M, Chen, D, Wang, S, Fu, P, Fan, W
• 其他作者: BIOLOGY
• 格式: Article
• 出版: Nature Publishing Group 2020
• 主題: histone deacetylase inhibitor; ligand; MICA protein; MICB protein; microRNA; microRNA 17 92; microRNA 20a; microRNA 20b; mitogen activated protein kinase; natural killer cell receptor NKG2D; ULBP1 protein; ULBP2 protein; ULBP3 protein; unclassified drug; KLRK1 protein, human; MIRN20 microRNA, human; natural killer cell lectin like receptor subfamily K; RNA; tumor protein; 3' untranslated region; animal experiment; animal model; antigen recognition; Article; BC cell line; Bcap37 cell line; binding site; breast cancer; breast tissue; BT-474 cell line; cancer patient; cancer prognosis; cancer staging; cancer survival; cancer tissue; controlled study; down regulation; enzyme inhibition; gene cluster; gene silencing; gene targeting; HS 578T cell line; human; human tissue; in vitro study; in vivo study; ligand binding; male; MAPK signaling; MCF-7 cell line; MDA-MB-231 cell line; MDA-MB-468 cell line; mouse; natural killer cell mediated cytotoxicity; nonhuman; overall survival; priority journal; protein analysis; protein expression; protein function; SK-BR-3 cell line; tumor immunogenicity; upregulation; animal; breast tumor; drug effects; female; genetics; immunology; natural killer cell; pathology; Animals; Breast Neoplasms; Female; Histone Deacetylase Inhibitors; Humans; Killer Cells, Natural; Male; MAP Kinase Signaling System; MCF-7 Cells; Mice; MicroRNAs; Neoplasm Proteins; NK Cell Lectin-Like Receptor Subfamily K; RNA, Neoplasm
• 在線閱讀: https://scholarbank.nus.edu.sg/handle/10635/179756
• 機構: National University of Singapore

10.1038/cddis.2017.158