Modulation of Mcl-1 sensitizes glioblastoma to TRAIL-induced apoptosis

• Main Authors: Murphy, A.C, Weyhenmeyer, B, Noonan, J, Kilbride, S.M, Schimansky, S, Loh, K.P, Kögel, D, Letai, A.G, Prehn, J.H.M, Murphy, B.M
• Other Authors: DEPT OF CHEMISTRY
• Format: Article
• Published: Kluwer Academic Publishers 2020
• Subjects: actin; caspase 3; caspase 8; FLICE inhibitory protein; procaspase 3; procaspase 8; protein Bid; protein mcl 1; protein Noxa; roscovitine; tumor necrosis factor related apoptosis inducing ligand; antineoplastic agent; MCL1 protein, human; myeloid leukemia factor 1; PMAIP1 protein, human; protein bcl 2; purine derivative; apoptosis; article; cell viability assay; controlled study; disease resistance; down regulation; enzyme activation; gene silencing; glioblastoma; glioma cell; human; human cell; human cell culture; neuromodulation; priority journal; protein expression; protein targeting; Brain Neoplasms; drug effects; drug potentiation; drug resistance; genetics; metabolism; pathology; tumor cell line; Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 8; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Activation; Gene Silencing; Glioblastoma; Humans; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2; Purines; TNF-Related Apoptosis-Inducing Ligand
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/180765
• Institution: National University of Singapore

10.1007/s10495-013-0935-2