Zoledronic acid prevents the tumor-promoting effects of mesenchymal stem cells via MCP-1 dependent recruitment of macrophages

• Main Authors: Jia, X.-H, Du, Y, Mao, D, Wang, Z.-L, He, Z.-Q, Qiu, J.-D, Ma, X.-B, Shang, W.-T, Ding, D, Tian, J
• Other Authors: CHEMICAL & BIOMOLECULAR ENGINEERING
• Format: Article
• Published: 2020
• Subjects: 5' nucleotidase; beta1 integrin; CD206 antigen; cell surface marker; endoglin; monocyte chemotactic protein 1; Thy 1 antigen; unclassified drug; zoledronic acid; bisphosphonic acid derivative; bone density conservation agent; cell surface receptor; cytokine; imidazole derivative; lectin; luciferase; mannose binding lectin; mannose receptor; animal cell; animal experiment; animal model; animal tissue; antiangiogenic activity; Article; breast cancer cell line; breast tumor; cancer inhibition; controlled study; female; gene expression; human; human cell; macrophage migration inhibition; male; mammary gland fat; mesenchymal stem cell; mouse; nonhuman; tumor associated leukocyte; tumor microenvironment; animal; Breast Neoplasms; C57BL mouse; cell culture; drug effects; drug screening; gene expression regulation; genetics; immunohistochemistry; luminescence; macrophage; Mammary Neoplasms, Experimental; mesenchymal stem cell transplantation; mesenchymal stroma cell; metabolism; nude mouse; procedures; reverse transcription polymerase chain reaction; RNA interference; tumor cell line; tumor volume; Animals; Bone Density Conservation Agents; Cell Line, Tumor; Cells, Cultured; Chemokine CCL2; Cytokines; Diphosphonates; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Immunohistochemistry; Lectins, C-Type; Luciferases; Luminescent Measurements; Macrophages; Mannose-Binding Lectins; Mesenchymal Stem Cell Transplantation; Mesenchymal Stromal Cells; Mice, Inbred C57BL; Mice, Nude; Receptors, Cell Surface; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Tumor Burden; Xenograft Model Antitumor Assays
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/180936
• Institution: National University of Singapore

10.18632/oncotarget.4658