Zoledronic acid prevents the tumor-promoting effects of mesenchymal stem cells via MCP-1 dependent recruitment of macrophages

Zoledronic acid prevents the tumor-promoting effects of mesenchymal stem cells via MCP-1 dependent recruitment of macrophages

10.18632/oncotarget.4658

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Bibliographic Details
Main Authors:	Jia, X.-H, Du, Y, Mao, D, Wang, Z.-L, He, Z.-Q, Qiu, J.-D, Ma, X.-B, Shang, W.-T, Ding, D, Tian, J
Other Authors:	CHEMICAL & BIOMOLECULAR ENGINEERING
Format:	Article
Published:	2020
Subjects:	5' nucleotidase beta1 integrin CD206 antigen cell surface marker endoglin monocyte chemotactic protein 1 Thy 1 antigen unclassified drug zoledronic acid bisphosphonic acid derivative bone density conservation agent cell surface receptor cytokine imidazole derivative lectin luciferase mannose binding lectin mannose receptor animal cell animal experiment animal model animal tissue antiangiogenic activity Article breast cancer cell line breast tumor cancer inhibition controlled study female gene expression human human cell macrophage migration inhibition male mammary gland fat mesenchymal stem cell mouse nonhuman tumor associated leukocyte tumor microenvironment animal Breast Neoplasms C57BL mouse cell culture drug effects drug screening gene expression regulation genetics immunohistochemistry luminescence macrophage Mammary Neoplasms, Experimental mesenchymal stem cell transplantation mesenchymal stroma cell metabolism nude mouse procedures reverse transcription polymerase chain reaction RNA interference tumor cell line tumor volume Animals Bone Density Conservation Agents Cell Line, Tumor Cells, Cultured Chemokine CCL2 Cytokines Diphosphonates Gene Expression Regulation, Neoplastic Humans Imidazoles Immunohistochemistry Lectins, C-Type Luciferases Luminescent Measurements Macrophages Mannose-Binding Lectins Mesenchymal Stem Cell Transplantation Mesenchymal Stromal Cells Mice, Inbred C57BL Mice, Nude Receptors, Cell Surface Reverse Transcriptase Polymerase Chain Reaction RNA Interference Tumor Burden Xenograft Model Antitumor Assays
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/180936
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Institution:	National University of Singapore

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