Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance

10.1158/0008-5472.CAN-07-5428

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Main Authors:	Shimamura, T, Li, D, Ji, H, Haringsma, H.J, Liniker, E, Borgman, C.L, Lowell, A.M, Minami, Y, McNamara, K, Perera, S.A, Zaghlul, S, Thomas, R.K, Greulich, H, Kobayashi, S, Chirieac, L.R, Padera, R.F, Kubo, S, Takahashi, M, Tenen, D.G, Meyerson, M, Wong, K.-K, Shapiro, G.I
Other Authors:	MEDICINE
Format:	Article
Published:	2020
Subjects:	17 demethoxy 17 (2 dimethylaminoethylamino)geldanamycin 3 bromo 5 tert butyl 4 hydroxybenzylidenemalononitrile 4 [3 chloro 4 (2 pyridinylmethoxy)anilino] 3 cyano 6 (4 dimethylaminocrotonamido) 7 ethoxyquinoline cl 387785 epidermal growth factor epidermal growth factor receptor kinase inhibitor erlotinib gefitinib heat shock protein 90 heat shock protein 90 inhibitor protein tyrosine kinase rapamycin tanespimycin unclassified drug antineoplastic agent enzyme inhibitor epidermal growth factor receptor mammalian target of rapamycin protein kinase article cancer cell culture cancer resistance cytotoxicity drug inhibition human immunohistochemistry lung non small cell cancer mutational analysis priority journal protein expression protein phosphorylation adenocarcinoma animal apoptosis drug resistance gene expression regulation genetics lung tumor metabolism mouse mutation pathology signal transduction tumor cell line Adenocarcinoma Animals Antineoplastic Agents Apoptosis Cell Line, Tumor Drug Resistance, Neoplasm Enzyme Inhibitors Gene Expression Regulation, Neoplastic HSP90 Heat-Shock Proteins Lung Neoplasms Mice Mutation Protein Kinases Receptor, Epidermal Growth Factor Signal Transduction
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/181021
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1810212024-11-08T21:07:51Z Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance Shimamura, T Li, D Ji, H Haringsma, H.J Liniker, E Borgman, C.L Lowell, A.M Minami, Y McNamara, K Perera, S.A Zaghlul, S Thomas, R.K Greulich, H Kobayashi, S Chirieac, L.R Padera, R.F Kubo, S Takahashi, M Tenen, D.G Meyerson, M Wong, K.-K Shapiro, G.I MEDICINE 17 demethoxy 17 (2 dimethylaminoethylamino)geldanamycin 3 bromo 5 tert butyl 4 hydroxybenzylidenemalononitrile 4 [3 chloro 4 (2 pyridinylmethoxy)anilino] 3 cyano 6 (4 dimethylaminocrotonamido) 7 ethoxyquinoline cl 387785 epidermal growth factor epidermal growth factor receptor kinase inhibitor erlotinib gefitinib heat shock protein 90 heat shock protein 90 inhibitor protein tyrosine kinase rapamycin tanespimycin unclassified drug antineoplastic agent enzyme inhibitor epidermal growth factor receptor heat shock protein 90 mammalian target of rapamycin protein kinase article cancer cell culture cancer resistance cytotoxicity drug inhibition human immunohistochemistry lung non small cell cancer mutational analysis priority journal protein expression protein phosphorylation adenocarcinoma animal apoptosis drug resistance gene expression regulation genetics lung tumor metabolism mouse mutation pathology signal transduction tumor cell line Adenocarcinoma Animals Antineoplastic Agents Apoptosis Cell Line, Tumor Drug Resistance, Neoplasm Enzyme Inhibitors Gene Expression Regulation, Neoplastic HSP90 Heat-Shock Proteins Lung Neoplasms Mice Mutation Protein Kinases Receptor, Epidermal Growth Factor Signal Transduction 10.1158/0008-5472.CAN-07-5428 Cancer Research 68 14 5827-5838 2020-10-27T06:55:55Z 2020-10-27T06:55:55Z 2008 Article Shimamura, T, Li, D, Ji, H, Haringsma, H.J, Liniker, E, Borgman, C.L, Lowell, A.M, Minami, Y, McNamara, K, Perera, S.A, Zaghlul, S, Thomas, R.K, Greulich, H, Kobayashi, S, Chirieac, L.R, Padera, R.F, Kubo, S, Takahashi, M, Tenen, D.G, Meyerson, M, Wong, K.-K, Shapiro, G.I (2008). Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance. Cancer Research 68 (14) : 5827-5838. ScholarBank@NUS Repository. https://doi.org/10.1158/0008-5472.CAN-07-5428 00085472 https://scholarbank.nus.edu.sg/handle/10635/181021 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	17 demethoxy 17 (2 dimethylaminoethylamino)geldanamycin 3 bromo 5 tert butyl 4 hydroxybenzylidenemalononitrile 4 [3 chloro 4 (2 pyridinylmethoxy)anilino] 3 cyano 6 (4 dimethylaminocrotonamido) 7 ethoxyquinoline cl 387785 epidermal growth factor epidermal growth factor receptor kinase inhibitor erlotinib gefitinib heat shock protein 90 heat shock protein 90 inhibitor protein tyrosine kinase rapamycin tanespimycin unclassified drug antineoplastic agent enzyme inhibitor epidermal growth factor receptor heat shock protein 90 mammalian target of rapamycin protein kinase article cancer cell culture cancer resistance cytotoxicity drug inhibition human immunohistochemistry lung non small cell cancer mutational analysis priority journal protein expression protein phosphorylation adenocarcinoma animal apoptosis drug resistance gene expression regulation genetics lung tumor metabolism mouse mutation pathology signal transduction tumor cell line Adenocarcinoma Animals Antineoplastic Agents Apoptosis Cell Line, Tumor Drug Resistance, Neoplasm Enzyme Inhibitors Gene Expression Regulation, Neoplastic HSP90 Heat-Shock Proteins Lung Neoplasms Mice Mutation Protein Kinases Receptor, Epidermal Growth Factor Signal Transduction
spellingShingle	17 demethoxy 17 (2 dimethylaminoethylamino)geldanamycin 3 bromo 5 tert butyl 4 hydroxybenzylidenemalononitrile 4 [3 chloro 4 (2 pyridinylmethoxy)anilino] 3 cyano 6 (4 dimethylaminocrotonamido) 7 ethoxyquinoline cl 387785 epidermal growth factor epidermal growth factor receptor kinase inhibitor erlotinib gefitinib heat shock protein 90 heat shock protein 90 inhibitor protein tyrosine kinase rapamycin tanespimycin unclassified drug antineoplastic agent enzyme inhibitor epidermal growth factor receptor heat shock protein 90 mammalian target of rapamycin protein kinase article cancer cell culture cancer resistance cytotoxicity drug inhibition human immunohistochemistry lung non small cell cancer mutational analysis priority journal protein expression protein phosphorylation adenocarcinoma animal apoptosis drug resistance gene expression regulation genetics lung tumor metabolism mouse mutation pathology signal transduction tumor cell line Adenocarcinoma Animals Antineoplastic Agents Apoptosis Cell Line, Tumor Drug Resistance, Neoplasm Enzyme Inhibitors Gene Expression Regulation, Neoplastic HSP90 Heat-Shock Proteins Lung Neoplasms Mice Mutation Protein Kinases Receptor, Epidermal Growth Factor Signal Transduction Shimamura, T Li, D Ji, H Haringsma, H.J Liniker, E Borgman, C.L Lowell, A.M Minami, Y McNamara, K Perera, S.A Zaghlul, S Thomas, R.K Greulich, H Kobayashi, S Chirieac, L.R Padera, R.F Kubo, S Takahashi, M Tenen, D.G Meyerson, M Wong, K.-K Shapiro, G.I Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance
description	10.1158/0008-5472.CAN-07-5428
author2	MEDICINE
author_facet	MEDICINE Shimamura, T Li, D Ji, H Haringsma, H.J Liniker, E Borgman, C.L Lowell, A.M Minami, Y McNamara, K Perera, S.A Zaghlul, S Thomas, R.K Greulich, H Kobayashi, S Chirieac, L.R Padera, R.F Kubo, S Takahashi, M Tenen, D.G Meyerson, M Wong, K.-K Shapiro, G.I
format	Article
author	Shimamura, T Li, D Ji, H Haringsma, H.J Liniker, E Borgman, C.L Lowell, A.M Minami, Y McNamara, K Perera, S.A Zaghlul, S Thomas, R.K Greulich, H Kobayashi, S Chirieac, L.R Padera, R.F Kubo, S Takahashi, M Tenen, D.G Meyerson, M Wong, K.-K Shapiro, G.I
author_sort	Shimamura, T
title	Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance
title_short	Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance
title_full	Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance
title_fullStr	Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance
title_full_unstemmed	Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance
title_sort	hsp90 inhibition suppresses mutant egfr-t790m signaling and overcomes kinase inhibitor resistance
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/181021
_version_	1821204934444449792

Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance

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