Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance

• Main Authors: Shimamura, T, Li, D, Ji, H, Haringsma, H.J, Liniker, E, Borgman, C.L, Lowell, A.M, Minami, Y, McNamara, K, Perera, S.A, Zaghlul, S, Thomas, R.K, Greulich, H, Kobayashi, S, Chirieac, L.R, Padera, R.F, Kubo, S, Takahashi, M, Tenen, D.G, Meyerson, M, Wong, K.-K, Shapiro, G.I
• Other Authors: MEDICINE
• Format: Article
• Published: 2020
• Subjects: 17 demethoxy 17 (2 dimethylaminoethylamino)geldanamycin; 3 bromo 5 tert butyl 4 hydroxybenzylidenemalononitrile; 4 [3 chloro 4 (2 pyridinylmethoxy)anilino] 3 cyano 6 (4 dimethylaminocrotonamido) 7 ethoxyquinoline; cl 387785; epidermal growth factor; epidermal growth factor receptor kinase inhibitor; erlotinib; gefitinib; heat shock protein 90; heat shock protein 90 inhibitor; protein tyrosine kinase; rapamycin; tanespimycin; unclassified drug; antineoplastic agent; enzyme inhibitor; epidermal growth factor receptor; mammalian target of rapamycin; protein kinase; article; cancer cell culture; cancer resistance; cytotoxicity; drug inhibition; human; immunohistochemistry; lung non small cell cancer; mutational analysis; priority journal; protein expression; protein phosphorylation; adenocarcinoma; animal; apoptosis; drug resistance; gene expression regulation; genetics; lung tumor; metabolism; mouse; mutation; pathology; signal transduction; tumor cell line; Adenocarcinoma; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Drug Resistance, Neoplasm; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; HSP90 Heat-Shock Proteins; Lung Neoplasms; Mice; Mutation; Protein Kinases; Receptor, Epidermal Growth Factor; Signal Transduction
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/181021
• Institution: National University of Singapore

10.1158/0008-5472.CAN-07-5428