Vaccaria hypaphorine alleviates lipopolysaccharide-induced inflammation via inactivation of NF?B and ERK pathways in Raw 264.7 cells

Vaccaria hypaphorine alleviates lipopolysaccharide-induced inflammation via inactivation of NF?B and ERK pathways in Raw 264.7 cells

10.1186/s12906-017-1635-1

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Bibliographic Details
Main Authors:	Sun, H, Cai, W, Wang, X, Liu, Y, Hou, B, Zhu, X, Qiu, L
Other Authors:	DEPT OF PHARMACOLOGY
Format:	Article
Published:	2020
Subjects:	acetylsalicylic acid antiinflammatory agent cyclooxygenase 2 dexamethasone herbaceous agent I kappa B kinase alpha I kappa B kinase beta immunoglobulin enhancer binding protein inducible nitric oxide synthase interleukin 10 interleukin 1beta interleukin 6 lipopolysaccharide messenger RNA mitogen activated protein kinase monocyte chemotactic protein 1 nitric oxide prostaglandin E2 transcription factor RelA tumor necrosis factor unclassified drug Vaccaria hypaphorine autacoid cytokine I kappa B kinase indole derivative lenticin plant extract animal cell antiinflammatory activity Article cell viability cellular distribution concentration response controlled study cytokine production down regulation drug effect drug mechanism enzyme inhibition enzyme phosphorylation gene expression regulation human human cell immunofluorescence in vitro study inflammation intracellular signaling lipopolysaccharide induced inflammation MCF-7 cell line molecular dynamics mouse nonhuman outcome assessment RAW 264.7 cell line animal chemically induced chemistry drug effects macrophage metabolism phosphorylation phytotherapy signal transduction transport at the cellular level Vaccaria Animals Anti-Inflammatory Agents Biological Transport Cyclooxygenase 2 Cytokines Humans I-kappa B Kinase Indoles Inflammation Inflammation Mediators Lipopolysaccharides Macrophages MAP Kinase Signaling System MCF-7 Cells Mice NF-kappa B NF-KappaB Inhibitor alpha Nitric Oxide Nitric Oxide Synthase Type II Phosphorylation Phytotherapy Plant Extracts RAW 264.7 Cells
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/181298
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Institution:	National University of Singapore

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Summary:	10.1186/s12906-017-1635-1