Inter-dependent mechanisms behind cognitive dysfunction, vascular biology and Alzheimer’s dementia in down syndrome: Multi-faceted roles of APP

Inter-dependent mechanisms behind cognitive dysfunction, vascular biology and Alzheimer’s dementia in down syndrome: Multi-faceted roles of APP

10.3389/fnbeh.2015.00299

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Bibliographic Details
Main Authors:	Nizetic, D, Chen, C.L, Hong, W, Koo, E.H
Other Authors:	PHARMACOLOGY
Format:	Article
Published:	2020
Subjects:	amyloid beta protein[1-40] amyloid beta protein[1-42] amyloid precursor protein calcium channel L type cyclin dependent kinase 5 ephrin receptor B2 Fc receptor IIb gamma secretase high density lipoprotein n methyl dextro aspartic acid prion protein sorting nexin sorting nexin 27 tau protein triacylglycerol unclassified drug Alzheimer disease Article binding affinity cell activity chromosome 21 cognition cognitive defect dendritic spine Down syndrome human lipid metabolism mild cognitive impairment nerve cell nerve cell plasticity nonhuman partial trisomy pathogenesis prevalence protein expression protein function protein secretion signal transduction vascular amyloidosis vascular biology
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/181414
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Institution:	National University of Singapore

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