Estradiol promotes the development of a fibrotic phenotype and is increased in the serum of patients with systemic sclerosis

• Main Authors: Aida-Yasuoka, K, Peoples, C, Yasuoka, H, Hershberger, P, Thiel, K, Cauley, J.A, Medsger, T.A, Feghali-Bostwick, C.A
• Other Authors: OBSTETRICS & GYNAECOLOGY
• Format: Article
• Published: 2020
• Subjects: 1,3,5 tris(4 hydroxyphenyl) 4 propylpyrazole; 1,4 diamino 1,4 bis(2 aminophenylthio) 2,3 dicyanobutadiene; 2 morpholino 8 phenylchromone; 4 (4 fluorophenyl) 2 (4 hydroxyphenyl) 5 (4 pyridyl)imidazole; estradiol; estrogen; estrogen receptor alpha; estrogen receptor beta; estrone; fibronectin; fulvestrant; genistein; inositol 1,4,5 triphosphate inhibitor; inositol 1,4,5 trisphosphate derivative; mitogen activated protein kinase p38 inhibitor; unclassified drug; estrogen receptor antagonist; adult; aged; article; blood sampling; clinical article; controlled study; drug effect; drug mechanism; estrogen blood level; estrone blood level; ex vivo study; human; human cell; human tissue; in vitro study; mass spectrometry; mediator; organ culture; phenotype; protein expression; serum; signal transduction; skin; skin fibroblast; skin fibrosis; systemic sclerosis; biosynthesis; blood; cell culture; drug effects; female; fibroblast; fibrosis; immunohistochemistry; liquid chromatography; metabolism; middle aged; pathology; physiology; reverse transcription polymerase chain reaction; tandem mass spectrometry; Western blotting; Aged; Blotting, Western; Cells, Cultured; Chromatography, Liquid; Estradiol; Estrogen Receptor Antagonists; Female; Fibroblasts; Fibronectins; Fibrosis; Humans; Immunohistochemistry; Middle Aged; Phenotype; Reverse Transcriptase Polymerase Chain Reaction; Scleroderma, Systemic; Signal Transduction; Tandem Mass Spectrometry
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/181581
• Institution: National University of Singapore

10.1186/ar4140