20(S)-Ginsenoside Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicin

10.18632/oncotarget.2034

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Main Authors:	Kim, D.-G, Jung, K.H, Lee, D.-G, Yoon, J.-H, Choi, K.S, Kwon, S.W, Shen, H.-M, Morgan, M.J, Hong, S.-S, Kim, Y.-S
Other Authors:	PHYSIOLOGY
Format:	Article
Published:	2020
Subjects:	autophagy protein 5 bafilomycin A1 caspase 3 chloroquine cycloheximide death receptor 5 doxorubicin ginsenoside Rg 3 growth arrest and DNA damage inducible protein 153 LC3 II protein membrane protein protein p62 unclassified drug antineoplastic antibiotic ginsenoside adjuvant therapy animal cell animal experiment animal model animal tissue article autophagosome autophagy cancer combination chemotherapy cancer inhibition cell death chemosensitization controlled study dose time effect relation drug effect drug efficacy drug inhibition drug mechanism drug potentiation drug response drug tolerability enantiomer enzyme activation gene expression ginseng in vitro study in vivo study liver cell carcinoma male mouse nonhuman protein cleavage protein stability tumor volume tumor xenograft upregulation Carcinoma, Hepatocellular female human Liver Neoplasms Antibiotics, Antineoplastic Autophagy Doxorubicin Female Ginsenosides Humans Male
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/181780
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1817802024-04-04T01:10:02Z 20(S)-Ginsenoside Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicin Kim, D.-G Jung, K.H Lee, D.-G Yoon, J.-H Choi, K.S Kwon, S.W Shen, H.-M Morgan, M.J Hong, S.-S Kim, Y.-S PHYSIOLOGY autophagy protein 5 bafilomycin A1 caspase 3 chloroquine cycloheximide death receptor 5 doxorubicin ginsenoside Rg 3 growth arrest and DNA damage inducible protein 153 LC3 II protein membrane protein protein p62 unclassified drug antineoplastic antibiotic doxorubicin ginsenoside ginsenoside Rg 3 adjuvant therapy animal cell animal experiment animal model animal tissue article autophagosome autophagy cancer combination chemotherapy cancer inhibition cell death chemosensitization controlled study dose time effect relation drug effect drug efficacy drug inhibition drug mechanism drug potentiation drug response drug tolerability enantiomer enzyme activation gene expression ginseng in vitro study in vivo study liver cell carcinoma male mouse nonhuman protein cleavage protein stability tumor volume tumor xenograft upregulation autophagy Carcinoma, Hepatocellular female human Liver Neoplasms Antibiotics, Antineoplastic Autophagy Carcinoma, Hepatocellular Doxorubicin Female Ginsenosides Humans Liver Neoplasms Male 10.18632/oncotarget.2034 Oncotarget 5 12 4438-4451 2020-10-28T07:12:20Z 2020-10-28T07:12:20Z 2014 Article Kim, D.-G, Jung, K.H, Lee, D.-G, Yoon, J.-H, Choi, K.S, Kwon, S.W, Shen, H.-M, Morgan, M.J, Hong, S.-S, Kim, Y.-S (2014). 20(S)-Ginsenoside Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicin. Oncotarget 5 (12) : 4438-4451. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.2034 19492553 https://scholarbank.nus.edu.sg/handle/10635/181780 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	autophagy protein 5 bafilomycin A1 caspase 3 chloroquine cycloheximide death receptor 5 doxorubicin ginsenoside Rg 3 growth arrest and DNA damage inducible protein 153 LC3 II protein membrane protein protein p62 unclassified drug antineoplastic antibiotic doxorubicin ginsenoside ginsenoside Rg 3 adjuvant therapy animal cell animal experiment animal model animal tissue article autophagosome autophagy cancer combination chemotherapy cancer inhibition cell death chemosensitization controlled study dose time effect relation drug effect drug efficacy drug inhibition drug mechanism drug potentiation drug response drug tolerability enantiomer enzyme activation gene expression ginseng in vitro study in vivo study liver cell carcinoma male mouse nonhuman protein cleavage protein stability tumor volume tumor xenograft upregulation autophagy Carcinoma, Hepatocellular female human Liver Neoplasms Antibiotics, Antineoplastic Autophagy Carcinoma, Hepatocellular Doxorubicin Female Ginsenosides Humans Liver Neoplasms Male
spellingShingle	autophagy protein 5 bafilomycin A1 caspase 3 chloroquine cycloheximide death receptor 5 doxorubicin ginsenoside Rg 3 growth arrest and DNA damage inducible protein 153 LC3 II protein membrane protein protein p62 unclassified drug antineoplastic antibiotic doxorubicin ginsenoside ginsenoside Rg 3 adjuvant therapy animal cell animal experiment animal model animal tissue article autophagosome autophagy cancer combination chemotherapy cancer inhibition cell death chemosensitization controlled study dose time effect relation drug effect drug efficacy drug inhibition drug mechanism drug potentiation drug response drug tolerability enantiomer enzyme activation gene expression ginseng in vitro study in vivo study liver cell carcinoma male mouse nonhuman protein cleavage protein stability tumor volume tumor xenograft upregulation autophagy Carcinoma, Hepatocellular female human Liver Neoplasms Antibiotics, Antineoplastic Autophagy Carcinoma, Hepatocellular Doxorubicin Female Ginsenosides Humans Liver Neoplasms Male Kim, D.-G Jung, K.H Lee, D.-G Yoon, J.-H Choi, K.S Kwon, S.W Shen, H.-M Morgan, M.J Hong, S.-S Kim, Y.-S 20(S)-Ginsenoside Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicin
description	10.18632/oncotarget.2034
author2	PHYSIOLOGY
author_facet	PHYSIOLOGY Kim, D.-G Jung, K.H Lee, D.-G Yoon, J.-H Choi, K.S Kwon, S.W Shen, H.-M Morgan, M.J Hong, S.-S Kim, Y.-S
format	Article
author	Kim, D.-G Jung, K.H Lee, D.-G Yoon, J.-H Choi, K.S Kwon, S.W Shen, H.-M Morgan, M.J Hong, S.-S Kim, Y.-S
author_sort	Kim, D.-G
title	20(S)-Ginsenoside Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicin
title_short	20(S)-Ginsenoside Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicin
title_full	20(S)-Ginsenoside Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicin
title_fullStr	20(S)-Ginsenoside Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicin
title_full_unstemmed	20(S)-Ginsenoside Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicin
title_sort	20(s)-ginsenoside rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicin
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/181780
_version_	1795374548328120320

20(S)-Ginsenoside Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicin

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