20(S)-Ginsenoside Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicin

• Main Authors: Kim, D.-G, Jung, K.H, Lee, D.-G, Yoon, J.-H, Choi, K.S, Kwon, S.W, Shen, H.-M, Morgan, M.J, Hong, S.-S, Kim, Y.-S
• Other Authors: PHYSIOLOGY
• Format: Article
• Published: 2020
• Subjects: autophagy protein 5; bafilomycin A1; caspase 3; chloroquine; cycloheximide; death receptor 5; doxorubicin; ginsenoside Rg 3; growth arrest and DNA damage inducible protein 153; LC3 II protein; membrane protein; protein p62; unclassified drug; antineoplastic antibiotic; ginsenoside; adjuvant therapy; animal cell; animal experiment; animal model; animal tissue; article; autophagosome; autophagy; cancer combination chemotherapy; cancer inhibition; cell death; chemosensitization; controlled study; dose time effect relation; drug effect; drug efficacy; drug inhibition; drug mechanism; drug potentiation; drug response; drug tolerability; enantiomer; enzyme activation; gene expression; ginseng; in vitro study; in vivo study; liver cell carcinoma; male; mouse; nonhuman; protein cleavage; protein stability; tumor volume; tumor xenograft; upregulation; Carcinoma, Hepatocellular; female; human; Liver Neoplasms; Antibiotics, Antineoplastic; Autophagy; Doxorubicin; Female; Ginsenosides; Humans; Male
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/181780
• Institution: National University of Singapore

10.18632/oncotarget.2034