C1q/TNF-related protein-9 ameliorates Ox-LDL-induced endothelial dysfunction via PGC-1²/AMPK-mediated antioxidant enzyme induction

• Main Authors: Sun, H, Zhu, X, Zhou, Y, Cai, W, Qiu, L
• Other Authors: DEPT OF PHARMACOLOGY
• Format: Article
• Published: MDPI 2020
• Subjects: complement component C1q; CXCL11 chemokine; endothelial nitric oxide synthase; glutamate cysteine ligase; heme oxygenase 1; nicotinamide adenine dinucleotide phosphate; nitric oxide; oxidized low density lipoprotein; peroxisome proliferator activated receptor gamma coactivator 1alpha; reactive oxygen metabolite; small interfering RNA; tumor necrosis factor; adiponectin; antioxidant; C1QTNF9B protein, human; glycoprotein; hydroxymethylglutaryl coenzyme A reductase kinase; low density lipoprotein; PPARGC1A protein, human; agar gel electrophoresis; apoptosis; Article; cell culture; cell cycle assay; cell migration assay; cell proliferation assay; controlled study; cytotoxicity; endothelial dysfunction; endothelium injury; genetic transfection; human; human cell; immunofluorescence test; oxidative stress; protein expression; TUNEL assay; umbilical vein endothelial cell; Western blotting; cell cycle; cell motion; cell proliferation; drug effects; endothelium; metabolism; oxidation reduction reaction; pathophysiology; Adiponectin; AMP-Activated Protein Kinases; Antioxidants; Apoptosis; Cell Cycle; Cell Movement; Cell Proliferation; Endothelium; Glycoproteins; Human Umbilical Vein Endothelial Cells; Humans; Lipoproteins, LDL; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Reactive Oxygen Species
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/183522
• Institution: National University of Singapore

10.3390/ijms18061097