Inhibition of autophagy induces retinal pigment epithelial cell damage by the lipofuscin fluorophore A2E

10.1016/j.fob.2014.11.003

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Main Authors:	Saadat, K.A.S.M, Murakami, Y, Tan, X, Nomura, Y, Yasukawa, T, Okada, E, Ikeda, Y, Yanagi, Y
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	2020
Subjects:	3 methyladenine adenosine triphosphate copper zinc superoxide dismutase lipofuscin lipofuscin pigment A2E manganese superoxide dismutase messenger RNA mitochondrial transcription factor A parkin peroxisome proliferator activated receptor gamma coactivator 1alpha peroxisome proliferator activated receptor gamma coactivator 1beta reactive oxygen metabolite transcription factor Nrf1 unclassified drug Article autophagosome autophagy cell damage cell death cell survival cell vacuole cell viability controlled study cytotoxicity gene expression human human cell culture mitochondrion pigment cell real time polymerase chain reaction spheroid cell transmission electron microscopy upregulation
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/183646
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Institution:	National University of Singapore

id	sg-nus-scholar.10635-183646
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spelling	sg-nus-scholar.10635-1836462023-08-07T09:15:31Z Inhibition of autophagy induces retinal pigment epithelial cell damage by the lipofuscin fluorophore A2E Saadat, K.A.S.M Murakami, Y Tan, X Nomura, Y Yasukawa, T Okada, E Ikeda, Y Yanagi, Y DUKE-NUS MEDICAL SCHOOL 3 methyladenine adenosine triphosphate copper zinc superoxide dismutase lipofuscin lipofuscin pigment A2E manganese superoxide dismutase messenger RNA mitochondrial transcription factor A parkin peroxisome proliferator activated receptor gamma coactivator 1alpha peroxisome proliferator activated receptor gamma coactivator 1beta reactive oxygen metabolite transcription factor Nrf1 unclassified drug Article autophagosome autophagy cell damage cell death cell survival cell vacuole cell viability controlled study cytotoxicity gene expression human human cell culture mitochondrion pigment cell real time polymerase chain reaction spheroid cell transmission electron microscopy upregulation 10.1016/j.fob.2014.11.003 FEBS Open Bio 4 1007-1014 2020-11-18T07:34:28Z 2020-11-18T07:34:28Z 2014 Article Saadat, K.A.S.M, Murakami, Y, Tan, X, Nomura, Y, Yasukawa, T, Okada, E, Ikeda, Y, Yanagi, Y (2014). Inhibition of autophagy induces retinal pigment epithelial cell damage by the lipofuscin fluorophore A2E. FEBS Open Bio 4 : 1007-1014. ScholarBank@NUS Repository. https://doi.org/10.1016/j.fob.2014.11.003 22115463 https://scholarbank.nus.edu.sg/handle/10635/183646 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	3 methyladenine adenosine triphosphate copper zinc superoxide dismutase lipofuscin lipofuscin pigment A2E manganese superoxide dismutase messenger RNA mitochondrial transcription factor A parkin peroxisome proliferator activated receptor gamma coactivator 1alpha peroxisome proliferator activated receptor gamma coactivator 1beta reactive oxygen metabolite transcription factor Nrf1 unclassified drug Article autophagosome autophagy cell damage cell death cell survival cell vacuole cell viability controlled study cytotoxicity gene expression human human cell culture mitochondrion pigment cell real time polymerase chain reaction spheroid cell transmission electron microscopy upregulation
spellingShingle	3 methyladenine adenosine triphosphate copper zinc superoxide dismutase lipofuscin lipofuscin pigment A2E manganese superoxide dismutase messenger RNA mitochondrial transcription factor A parkin peroxisome proliferator activated receptor gamma coactivator 1alpha peroxisome proliferator activated receptor gamma coactivator 1beta reactive oxygen metabolite transcription factor Nrf1 unclassified drug Article autophagosome autophagy cell damage cell death cell survival cell vacuole cell viability controlled study cytotoxicity gene expression human human cell culture mitochondrion pigment cell real time polymerase chain reaction spheroid cell transmission electron microscopy upregulation Saadat, K.A.S.M Murakami, Y Tan, X Nomura, Y Yasukawa, T Okada, E Ikeda, Y Yanagi, Y Inhibition of autophagy induces retinal pigment epithelial cell damage by the lipofuscin fluorophore A2E
description	10.1016/j.fob.2014.11.003
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Saadat, K.A.S.M Murakami, Y Tan, X Nomura, Y Yasukawa, T Okada, E Ikeda, Y Yanagi, Y
format	Article
author	Saadat, K.A.S.M Murakami, Y Tan, X Nomura, Y Yasukawa, T Okada, E Ikeda, Y Yanagi, Y
author_sort	Saadat, K.A.S.M
title	Inhibition of autophagy induces retinal pigment epithelial cell damage by the lipofuscin fluorophore A2E
title_short	Inhibition of autophagy induces retinal pigment epithelial cell damage by the lipofuscin fluorophore A2E
title_full	Inhibition of autophagy induces retinal pigment epithelial cell damage by the lipofuscin fluorophore A2E
title_fullStr	Inhibition of autophagy induces retinal pigment epithelial cell damage by the lipofuscin fluorophore A2E
title_full_unstemmed	Inhibition of autophagy induces retinal pigment epithelial cell damage by the lipofuscin fluorophore A2E
title_sort	inhibition of autophagy induces retinal pigment epithelial cell damage by the lipofuscin fluorophore a2e
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/183646
_version_	1779153114329251840

Inhibition of autophagy induces retinal pigment epithelial cell damage by the lipofuscin fluorophore A2E

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