Inhibition of autophagy induces retinal pigment epithelial cell damage by the lipofuscin fluorophore A2E

• Main Authors: Saadat, K.A.S.M, Murakami, Y, Tan, X, Nomura, Y, Yasukawa, T, Okada, E, Ikeda, Y, Yanagi, Y
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2020
• Subjects: 3 methyladenine; adenosine triphosphate; copper zinc superoxide dismutase; lipofuscin; lipofuscin pigment A2E; manganese superoxide dismutase; messenger RNA; mitochondrial transcription factor A; parkin; peroxisome proliferator activated receptor gamma coactivator 1alpha; peroxisome proliferator activated receptor gamma coactivator 1beta; reactive oxygen metabolite; transcription factor Nrf1; unclassified drug; Article; autophagosome; autophagy; cell damage; cell death; cell survival; cell vacuole; cell viability; controlled study; cytotoxicity; gene expression; human; human cell culture; mitochondrion; pigment cell; real time polymerase chain reaction; spheroid cell; transmission electron microscopy; upregulation
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/183646
• Institution: National University of Singapore

10.1016/j.fob.2014.11.003