HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore

10.1093/cvr/cvu172

Saved in:

Bibliographic Details
Main Authors:	Ong, S.-G, Lee, W.H, Theodorou, L, Kodo, K, Lim, S.Y, Shukla, D.H, Briston, T, Kiriakidis, S, Ashcroft, M, Davidson, S.M, Maxwell, P.H, Yellon, D.M, Hausenloy, D.J
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	2020
Subjects:	glycogen synthase kinase 360a hexokinase hexokinase ii hypoxia inducible factor 1 hypoxia inducible factor 1alpha mitochondrial permeability transition pore phosphoinositide dependent protein kinase 1 procollagen proline 2 oxoglutarate 4 dioxygenase protein serine threonine kinase inhibitor pyruvate dehydrogenase kinase unclassified drug von Hippel Lindau protein carrier protein hexokinase 2, mouse Hif1a protein, mouse Hif1a protein, rat prolyl hydroxylase inhibitor protein serine threonine kinase pyruvate dehydrogenase (acetyl-transferring) kinase Vhlh protein, mouse animal cell animal experiment animal model Article cell metabolism controlled study enzyme inhibition ex vivo study gene expression glycolysis heart infarction heart muscle cell heart protection immunoblotting in vitro study in vivo study ischemia male mitochondrial membrane potential mouse nonhuman oxidative stress oxygen consumption rat reperfusion injury animal cardiac muscle disease model dose response drug effects genetics heart mitochondrion knockout mouse metabolism Myocardial Infarction Myocardial Reperfusion Injury pathology protein stability signal transduction Sprague Dawley rat time factor Animals Disease Models, Animal Dose-Response Relationship, Drug Glycolysis Hexokinase Hypoxia-Inducible Factor 1, alpha Subunit Male Mice, Knockout Mitochondria, Heart Mitochondrial Membrane Transport Proteins Myocardium Oxidative Stress Prolyl-Hydroxylase Inhibitors Protein Stability Protein-Serine-Threonine Kinases Rats, Sprague-Dawley Signal Transduction Time Factors Von Hippel-Lindau Tumor Suppressor Protein
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/183703
Tags:	Add Tag No Tags, Be the first to tag this record!
Institution:	National University of Singapore

id	sg-nus-scholar.10635-183703
record_format	dspace
spelling	sg-nus-scholar.10635-1837032023-09-14T22:39:40Z HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore Ong, S.-G Lee, W.H Theodorou, L Kodo, K Lim, S.Y Shukla, D.H Briston, T Kiriakidis, S Ashcroft, M Davidson, S.M Maxwell, P.H Yellon, D.M Hausenloy, D.J DUKE-NUS MEDICAL SCHOOL glycogen synthase kinase 360a hexokinase hexokinase ii hypoxia inducible factor 1 hypoxia inducible factor 1alpha mitochondrial permeability transition pore phosphoinositide dependent protein kinase 1 procollagen proline 2 oxoglutarate 4 dioxygenase protein serine threonine kinase inhibitor pyruvate dehydrogenase kinase unclassified drug von Hippel Lindau protein carrier protein hexokinase hexokinase 2, mouse Hif1a protein, mouse Hif1a protein, rat hypoxia inducible factor 1alpha mitochondrial permeability transition pore prolyl hydroxylase inhibitor protein serine threonine kinase pyruvate dehydrogenase (acetyl-transferring) kinase Vhlh protein, mouse von Hippel Lindau protein animal cell animal experiment animal model Article cell metabolism controlled study enzyme inhibition ex vivo study gene expression glycolysis heart infarction heart muscle cell heart protection immunoblotting in vitro study in vivo study ischemia male mitochondrial membrane potential mouse nonhuman oxidative stress oxygen consumption rat reperfusion injury animal cardiac muscle disease model dose response drug effects genetics heart mitochondrion knockout mouse metabolism Myocardial Infarction Myocardial Reperfusion Injury pathology protein stability signal transduction Sprague Dawley rat time factor Animals Disease Models, Animal Dose-Response Relationship, Drug Glycolysis Hexokinase Hypoxia-Inducible Factor 1, alpha Subunit Male Mice, Knockout Mitochondria, Heart Mitochondrial Membrane Transport Proteins Myocardial Infarction Myocardial Reperfusion Injury Myocardium Oxidative Stress Prolyl-Hydroxylase Inhibitors Protein Stability Protein-Serine-Threonine Kinases Rats, Sprague-Dawley Signal Transduction Time Factors Von Hippel-Lindau Tumor Suppressor Protein 10.1093/cvr/cvu172 Cardiovascular Research 104 1 24-36 2020-11-19T07:16:19Z 2020-11-19T07:16:19Z 2014 Article Ong, S.-G, Lee, W.H, Theodorou, L, Kodo, K, Lim, S.Y, Shukla, D.H, Briston, T, Kiriakidis, S, Ashcroft, M, Davidson, S.M, Maxwell, P.H, Yellon, D.M, Hausenloy, D.J (2014). HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore. Cardiovascular Research 104 (1) : 24-36. ScholarBank@NUS Repository. https://doi.org/10.1093/cvr/cvu172 00086363 https://scholarbank.nus.edu.sg/handle/10635/183703 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	glycogen synthase kinase 360a hexokinase hexokinase ii hypoxia inducible factor 1 hypoxia inducible factor 1alpha mitochondrial permeability transition pore phosphoinositide dependent protein kinase 1 procollagen proline 2 oxoglutarate 4 dioxygenase protein serine threonine kinase inhibitor pyruvate dehydrogenase kinase unclassified drug von Hippel Lindau protein carrier protein hexokinase hexokinase 2, mouse Hif1a protein, mouse Hif1a protein, rat hypoxia inducible factor 1alpha mitochondrial permeability transition pore prolyl hydroxylase inhibitor protein serine threonine kinase pyruvate dehydrogenase (acetyl-transferring) kinase Vhlh protein, mouse von Hippel Lindau protein animal cell animal experiment animal model Article cell metabolism controlled study enzyme inhibition ex vivo study gene expression glycolysis heart infarction heart muscle cell heart protection immunoblotting in vitro study in vivo study ischemia male mitochondrial membrane potential mouse nonhuman oxidative stress oxygen consumption rat reperfusion injury animal cardiac muscle disease model dose response drug effects genetics heart mitochondrion knockout mouse metabolism Myocardial Infarction Myocardial Reperfusion Injury pathology protein stability signal transduction Sprague Dawley rat time factor Animals Disease Models, Animal Dose-Response Relationship, Drug Glycolysis Hexokinase Hypoxia-Inducible Factor 1, alpha Subunit Male Mice, Knockout Mitochondria, Heart Mitochondrial Membrane Transport Proteins Myocardial Infarction Myocardial Reperfusion Injury Myocardium Oxidative Stress Prolyl-Hydroxylase Inhibitors Protein Stability Protein-Serine-Threonine Kinases Rats, Sprague-Dawley Signal Transduction Time Factors Von Hippel-Lindau Tumor Suppressor Protein
spellingShingle	glycogen synthase kinase 360a hexokinase hexokinase ii hypoxia inducible factor 1 hypoxia inducible factor 1alpha mitochondrial permeability transition pore phosphoinositide dependent protein kinase 1 procollagen proline 2 oxoglutarate 4 dioxygenase protein serine threonine kinase inhibitor pyruvate dehydrogenase kinase unclassified drug von Hippel Lindau protein carrier protein hexokinase hexokinase 2, mouse Hif1a protein, mouse Hif1a protein, rat hypoxia inducible factor 1alpha mitochondrial permeability transition pore prolyl hydroxylase inhibitor protein serine threonine kinase pyruvate dehydrogenase (acetyl-transferring) kinase Vhlh protein, mouse von Hippel Lindau protein animal cell animal experiment animal model Article cell metabolism controlled study enzyme inhibition ex vivo study gene expression glycolysis heart infarction heart muscle cell heart protection immunoblotting in vitro study in vivo study ischemia male mitochondrial membrane potential mouse nonhuman oxidative stress oxygen consumption rat reperfusion injury animal cardiac muscle disease model dose response drug effects genetics heart mitochondrion knockout mouse metabolism Myocardial Infarction Myocardial Reperfusion Injury pathology protein stability signal transduction Sprague Dawley rat time factor Animals Disease Models, Animal Dose-Response Relationship, Drug Glycolysis Hexokinase Hypoxia-Inducible Factor 1, alpha Subunit Male Mice, Knockout Mitochondria, Heart Mitochondrial Membrane Transport Proteins Myocardial Infarction Myocardial Reperfusion Injury Myocardium Oxidative Stress Prolyl-Hydroxylase Inhibitors Protein Stability Protein-Serine-Threonine Kinases Rats, Sprague-Dawley Signal Transduction Time Factors Von Hippel-Lindau Tumor Suppressor Protein Ong, S.-G Lee, W.H Theodorou, L Kodo, K Lim, S.Y Shukla, D.H Briston, T Kiriakidis, S Ashcroft, M Davidson, S.M Maxwell, P.H Yellon, D.M Hausenloy, D.J HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore
description	10.1093/cvr/cvu172
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Ong, S.-G Lee, W.H Theodorou, L Kodo, K Lim, S.Y Shukla, D.H Briston, T Kiriakidis, S Ashcroft, M Davidson, S.M Maxwell, P.H Yellon, D.M Hausenloy, D.J
format	Article
author	Ong, S.-G Lee, W.H Theodorou, L Kodo, K Lim, S.Y Shukla, D.H Briston, T Kiriakidis, S Ashcroft, M Davidson, S.M Maxwell, P.H Yellon, D.M Hausenloy, D.J
author_sort	Ong, S.-G
title	HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore
title_short	HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore
title_full	HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore
title_fullStr	HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore
title_full_unstemmed	HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore
title_sort	hif-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/183703
_version_	1779153127204716544

HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore

Similar Items