HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore

HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore

10.1093/cvr/cvu172

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Bibliographic Details
Main Authors:	Ong, S.-G, Lee, W.H, Theodorou, L, Kodo, K, Lim, S.Y, Shukla, D.H, Briston, T, Kiriakidis, S, Ashcroft, M, Davidson, S.M, Maxwell, P.H, Yellon, D.M, Hausenloy, D.J
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	2020
Subjects:	glycogen synthase kinase 360a hexokinase hexokinase ii hypoxia inducible factor 1 hypoxia inducible factor 1alpha mitochondrial permeability transition pore phosphoinositide dependent protein kinase 1 procollagen proline 2 oxoglutarate 4 dioxygenase protein serine threonine kinase inhibitor pyruvate dehydrogenase kinase unclassified drug von Hippel Lindau protein carrier protein hexokinase 2, mouse Hif1a protein, mouse Hif1a protein, rat prolyl hydroxylase inhibitor protein serine threonine kinase pyruvate dehydrogenase (acetyl-transferring) kinase Vhlh protein, mouse animal cell animal experiment animal model Article cell metabolism controlled study enzyme inhibition ex vivo study gene expression glycolysis heart infarction heart muscle cell heart protection immunoblotting in vitro study in vivo study ischemia male mitochondrial membrane potential mouse nonhuman oxidative stress oxygen consumption rat reperfusion injury animal cardiac muscle disease model dose response drug effects genetics heart mitochondrion knockout mouse metabolism Myocardial Infarction Myocardial Reperfusion Injury pathology protein stability signal transduction Sprague Dawley rat time factor Animals Disease Models, Animal Dose-Response Relationship, Drug Glycolysis Hexokinase Hypoxia-Inducible Factor 1, alpha Subunit Male Mice, Knockout Mitochondria, Heart Mitochondrial Membrane Transport Proteins Myocardium Oxidative Stress Prolyl-Hydroxylase Inhibitors Protein Stability Protein-Serine-Threonine Kinases Rats, Sprague-Dawley Signal Transduction Time Factors Von Hippel-Lindau Tumor Suppressor Protein
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/183703
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Institution:	National University of Singapore

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