HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore

• Main Authors: Ong, S.-G, Lee, W.H, Theodorou, L, Kodo, K, Lim, S.Y, Shukla, D.H, Briston, T, Kiriakidis, S, Ashcroft, M, Davidson, S.M, Maxwell, P.H, Yellon, D.M, Hausenloy, D.J
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2020
• Subjects: glycogen synthase kinase 360a; hexokinase; hexokinase ii; hypoxia inducible factor 1; hypoxia inducible factor 1alpha; mitochondrial permeability transition pore; phosphoinositide dependent protein kinase 1; procollagen proline 2 oxoglutarate 4 dioxygenase; protein serine threonine kinase inhibitor; pyruvate dehydrogenase kinase; unclassified drug; von Hippel Lindau protein; carrier protein; hexokinase 2, mouse; Hif1a protein, mouse; Hif1a protein, rat; prolyl hydroxylase inhibitor; protein serine threonine kinase; pyruvate dehydrogenase (acetyl-transferring) kinase; Vhlh protein, mouse; animal cell; animal experiment; animal model; Article; cell metabolism; controlled study; enzyme inhibition; ex vivo study; gene expression; glycolysis; heart infarction; heart muscle cell; heart protection; immunoblotting; in vitro study; in vivo study; ischemia; male; mitochondrial membrane potential; mouse; nonhuman; oxidative stress; oxygen consumption; rat; reperfusion injury; animal; cardiac muscle; disease model; dose response; drug effects; genetics; heart mitochondrion; knockout mouse; metabolism; Myocardial Infarction; Myocardial Reperfusion Injury; pathology; protein stability; signal transduction; Sprague Dawley rat; time factor; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Glycolysis; Hexokinase; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice, Knockout; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Myocardium; Oxidative Stress; Prolyl-Hydroxylase Inhibitors; Protein Stability; Protein-Serine-Threonine Kinases; Rats, Sprague-Dawley; Signal Transduction; Time Factors; Von Hippel-Lindau Tumor Suppressor Protein
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/183703
• Institution: National University of Singapore

10.1093/cvr/cvu172