Species-dependent and receptor-selective action of bilobalide on the function of constitutive androstane receptor and pregnane X receptor

• Main Authors: Lau, A.J, Yang, G, Rajaraman, G, Baucom, C.C, Chang, T.K.H
• Other Authors: PHARMACY
• Format: Article
• Published: American Society for Pharmacology and Experimental Therapeutics 2020
• Subjects: 16alpha cyanopregnenolone; bilobalide; constitutive androstane receptor; cytochrome P450 2B; cytochrome P450 2B1; cytochrome P450 2B6; cytochrome P450 3A; cytochrome P450 3A23; cytochrome P450 3A4; messenger RNA; pregnane X receptor; rifampicin; unclassified drug; animal cell; article; concentration response; controlled study; drug mechanism; enzyme activation; enzyme activity; gene expression; gene location; gene targeting; human; human cell; hydroxylation; liver cell; nonhuman; nucleotide sequence; priority journal; protein function; protein localization; protein targeting; rat; reporter gene; Animals; Cell Line, Tumor; Cells, Cultured; Cyclopentanes; Furans; Ginkgolides; Hep G2 Cells; Hepatocytes; Humans; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Species Specificity
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/183910
• Institution: National University of Singapore

10.1124/dmd.111.042879