Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation

• Main Authors: Kharazi, S, Mead, A.J, Mansour, A, Hultquist, A, Böiers, C, Luc, S, Buza-Vidas, N, Ma, Z, Ferry, H, Atkinson, D, Reckzeh, K, Masson, K, Cammenga, J, Rönnstrand, L, Arai, F, Suda, T, Nerlov, C, Sitnicka, E, Jacobsen, S.E.W
• Other Authors: MEDICINE
• Format: Article
• Published: American Society of Hematology 2020
• Subjects: ataxin 1; Flt3 ligand; stem cell factor; allele; animal experiment; animal model; article; cell expansion; controlled study; cytokine production; gene dosage; gene duplication; gene loss; gene targeting; granulocyte; internal tandem duplication; monocyte; mouse; myeloproliferative disorder; nonhuman; phenotype; priority journal; wild type; Alleles; Animals; Bone Marrow Cells; Cell Proliferation; Cells, Cultured; fms-Like Tyrosine Kinase 3; Gene Dosage; Gene Duplication; Gene Knock-In Techniques; Loss of Heterozygosity; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myeloproliferative Disorders; Phenotype; Tandem Repeat Sequences
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/183912
• Institution: National University of Singapore

10.1182/blood-2010-06-289207